Henipavirus Receptor Usage and Tropism

Overview

Journal Curr Top Microbiol Immunol

Specialties Allergy & Immunology
Microbiology

Date 2012 Jun 15

PMID 22695915

Citations 39

Authors

Olivier Pernet

Yao E Wang

Benhur Lee

Affiliations

Soon will be listed here.

Abstract

Nipah (NiV) and Hendra (HeV) viruses are the deadliest human pathogens within the Paramyxoviridae family, which include human and animal pathogens of global biomedical importance. NiV and HeV infections cause respiratory and encephalitic illness with high mortality rates in humans. Henipaviruses (HNV) are the only Paramyxoviruses classified as biosafety level 4 (BSL4) pathogens due to their extreme pathogenicity, potential for bioterrorism, and lack of licensed vaccines and therapeutics. HNV use ephrin-B2 and ephrin-B3, highly conserved proteins, as viral entry receptors. This likely accounts for their unusually broad species tropism, and also provides opportunities to study how receptor usage, cellular tropism, and end-organ pathology relates to the pathobiology of HNV infections. The clinical and pathologic manifestations of NiV and HeV virus infections are reviewed in the chapters by Wong et al. and Geisbert et al. in this issue. Here, we will review the biology of the HNV receptors, and how receptor usage relates to HNV cell tropism in vitro and in vivo.

Citing Articles

Pandemic potential of the Nipah virus and public health strategies adopted during outbreaks: Lessons from Kerala, India.

Anish T, Aravind R, Radhakrishnan C, Gupta N, Yadav P, Cherian J PLOS Glob Public Health. 2024; 4(12):e0003926.

PMID: 39700307 PMC: 11658523. DOI: 10.1371/journal.pgph.0003926.

Zoonotic Paramyxoviruses: Evolution, Ecology, and Public Health Strategies in a Changing World.

Branda F, Pavia G, Ciccozzi A, Quirino A, Marascio N, Matera G Viruses. 2024; 16(11).

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Novel transcription and replication-competent virus-like particles system modelling the Nipah virus life cycle.

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PMID: 38865205 PMC: 11229746. DOI: 10.1080/22221751.2024.2368217.

Vascular dysfunction in hemorrhagic viral fevers: opportunities for organotypic modeling.

Zarate-Sanchez E, George S, L Moya M, Robertson C Biofabrication. 2024; 16(3).

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Functional and antigenic landscape of the Nipah virus receptor binding protein.

Larsen B, McMahon T, Brown J, Wang Z, Radford C, Crowe Jr J bioRxiv. 2024; .

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References

Plowright R, Field H, Smith C, Divljan A, Palmer C, Tabor G . Reproduction and nutritional stress are risk factors for Hendra virus infection in little red flying foxes (Pteropus scapulatus). Proc Biol Sci. 2008; 275(1636):861-9. PMC: 2596896. DOI: 10.1098/rspb.2007.1260. View

Zhao C, Irie N, Takada Y, Shimoda K, Miyamoto T, Nishiwaki T . Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab. 2006; 4(2):111-21. DOI: 10.1016/j.cmet.2006.05.012. View

Wong K, Shieh W, Kumar S, Norain K, Abdullah W, Guarner J . Nipah virus infection: pathology and pathogenesis of an emerging paramyxoviral zoonosis. Am J Pathol. 2002; 161(6):2153-67. PMC: 1850894. DOI: 10.1016/S0002-9440(10)64493-8. View

Hafner C, Becker B, Landthaler M, Vogt T . Expression profile of Eph receptors and ephrin ligands in human skin and downregulation of EphA1 in nonmelanoma skin cancer. Mod Pathol. 2006; 19(10):1369-77. DOI: 10.1038/modpathol.3800660. View

Yoneda M, Guillaume V, Ikeda F, Sakuma Y, Sato H, Wild T . Establishment of a Nipah virus rescue system. Proc Natl Acad Sci U S A. 2006; 103(44):16508-13. PMC: 1618306. DOI: 10.1073/pnas.0606972103. View

Wacharapluesadee S, Boongird K, Wanghongsa S, Ratanasetyuth N, Supavonwong P, Saengsen D . A longitudinal study of the prevalence of Nipah virus in Pteropus lylei bats in Thailand: evidence for seasonal preference in disease transmission. Vector Borne Zoonotic Dis. 2009; 10(2):183-90. DOI: 10.1089/vbz.2008.0105. View

Mills J, Alim A, Bunning M, Lee O, Wagoner K, Amman B . Nipah virus infection in dogs, Malaysia, 1999. Emerg Infect Dis. 2009; 15(6):950-2. PMC: 2727347. DOI: 10.3201/eid1506.080453. View

Lee B, Ataman Z . Modes of paramyxovirus fusion: a Henipavirus perspective. Trends Microbiol. 2011; 19(8):389-99. PMC: 3264399. DOI: 10.1016/j.tim.2011.03.005. View

Rahman M, Hossain M, Sultana S, Homaira N, Khan S, Rahman M . Date palm sap linked to Nipah virus outbreak in Bangladesh, 2008. Vector Borne Zoonotic Dis. 2011; 12(1):65-72. DOI: 10.1089/vbz.2011.0656. View

10.

Tan C, Chua K . Nipah virus encephalitis. Curr Infect Dis Rep. 2008; 10(4):315-20. DOI: 10.1007/s11908-008-0051-6. View

11.

Georgakopoulos A, Litterst C, Ghersi E, Baki L, Xu C, Serban G . Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. EMBO J. 2006; 25(6):1242-52. PMC: 1422162. DOI: 10.1038/sj.emboj.7601031. View

12.

Cowan C, Henkemeyer M . The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals. Nature. 2001; 413(6852):174-9. DOI: 10.1038/35093123. View

13.

Li Y, Wang J, Hickey A, Zhang Y, Li Y, Wu Y . Antibodies to Nipah or Nipah-like viruses in bats, China. Emerg Infect Dis. 2008; 14(12):1974-6. PMC: 2634619. DOI: 10.3201/eid1412.080359. View

14.

Tatsuo H, Ono N, Tanaka K, Yanagi Y . SLAM (CDw150) is a cellular receptor for measles virus. Nature. 2000; 406(6798):893-7. DOI: 10.1038/35022579. View

15.

Young P, Halpin K, Selleck P, Field H, Gravel J, Kelly M . Serologic evidence for the presence in Pteropus bats of a paramyxovirus related to equine morbillivirus. Emerg Infect Dis. 1996; 2(3):239-40. PMC: 2626799. DOI: 10.3201/eid0203.960315. View

16.

Yuan J, Marsh G, Khetawat D, Broder C, Wang L, Shi Z . Mutations in the G-H loop region of ephrin-B2 can enhance Nipah virus binding and infection. J Gen Virol. 2011; 92(Pt 9):2142-2152. PMC: 7879936. DOI: 10.1099/vir.0.033787-0. View

17.

Holmberg J, Frisen J . Ephrins are not only unattractive. Trends Neurosci. 2002; 25(5):239-43. DOI: 10.1016/s0166-2236(02)02149-5. View

18.

Bossart K, Crameri G, Dimitrov A, Mungall B, Feng Y, Patch J . Receptor binding, fusion inhibition, and induction of cross-reactive neutralizing antibodies by a soluble G glycoprotein of Hendra virus. J Virol. 2005; 79(11):6690-702. PMC: 1112112. DOI: 10.1128/JVI.79.11.6690-6702.2005. View

19.

Hsu V, Hossain M, Parashar U, Ali M, Ksiazek T, Kuzmin I . Nipah virus encephalitis reemergence, Bangladesh. Emerg Infect Dis. 2005; 10(12):2082-7. PMC: 3323384. DOI: 10.3201/eid1012.040701. View

20.

Bossart K, Zhu Z, Middleton D, Klippel J, Crameri G, Bingham J . A neutralizing human monoclonal antibody protects against lethal disease in a new ferret model of acute nipah virus infection. PLoS Pathog. 2009; 5(10):e1000642. PMC: 2765826. DOI: 10.1371/journal.ppat.1000642. View