A Reductive-Heck Approach to the Hydroazulene Ring System: a Formal Synthesis of the Englerins

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2012 Jun 12

PMID 22679931

Citations 12

Authors

Peng Gao

Silas P Cook

Affiliations

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Abstract

The reduction of a palladium enolate prior to β-hydride elimination provides a unique reaction for the synthesis of the hydroazulene ring system. When combined with a transannular epoxide rearrangement cascade, the reductive-Heck reaction allows rapid entry to the oxo-bridged guaiane core of the englerins.

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