The Expression and Distribution of Xenogeneic Targeted Antigens on Porcine Bone Tissue

Overview

Journal Transplant Proc

Specialty General Surgery

Date 2012 Jun 6

PMID 22664027

Citations 6

Authors

W Feng

L Fu

J Liu

D Li

Affiliations

Soon will be listed here.

Abstract

Objective: The objective of this study was to investigate the distribution of α-galactosyl (α-Gal), major histocompatibility complex (MHC)-I, and MHC-II antigens on adult porcine bone tissue.

Methods: Distribution of α-Gal, MHC-I, and MHC-II antigens on porcine bone tissue were observed using immunohistochemistry.

Results: α-Gal, MHC-I xenogeneic antigens were extensively observed on the surface of bone marrow cells, osteocytes, osteoblasts, and Harversian canals; MHC-II antigens were mainly expressed on bone marrow cells.

Conclusion: α-Gal, MHC-I, and MHC-II are the main xenogeneic antigens that must be deleted to avoid xenogeneic immune reactions against bone xenografts.

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