Polyhexamethylene Biguanide Functionalized Cationic Silver Nanoparticles for Enhanced Antimicrobial Activity

Overview

Journal Nanoscale Res Lett

Publisher Springer

Specialty Biotechnology

Date 2012 May 26

PMID 22625664

Citations 19

Authors

Sumaira Ashraf

Nasrin Akhtar

Muhammad Afzal Ghauri

Muhammad Ibrahim Rajoka

Zafar M Khalid

Irshad Hussain

Affiliations

Soon will be listed here.

Abstract

Polyhexamethylene biguanide (PHMB), a broad spectrum disinfectant against many pathogens, was used as a stabilizing ligand for the synthesis of fairly uniform silver nanoparticles. The particles formed were characterized using UV-visible spectroscopy, FTIR, dynamic light scattering, electrophoretic mobility, and TEM to measure their morphology and surface chemistry. PHMB-functionalized silver nanoparticles were then evaluated for their antimicrobial activity against a gram-negative bacterial strain, Escherichia coli. These silver nanoparticles were found to have about 100 times higher bacteriostatic and bactericidal activities, compared to the previous reports, due to the combined antibacterial effect of silver nanoparticles and PHMB. In addition to other applications, PHMB-functionalized silver nanoparticles would be extremely useful in textile industry due to the strong interaction of PHMB with cellulose fabrics.

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