Guidance of Longitudinally Projecting Axons in the Developing Central Nervous System

Overview

Journal Front Mol Neurosci

Specialty Molecular Biology

Date 2012 May 16

PMID 22586366

Citations 11

Authors

Nozomi Sakai

Zaven Kaprielian

Affiliations

Soon will be listed here.

Abstract

The directed and stereotypical growth of axons to their synaptic targets is a crucial phase of neural circuit formation. Many axons in the developing vertebrate and invertebrate central nervous systems (CNSs), including those that remain on their own (ipsilateral), and those that cross over to the opposite (commissural), side of the midline project over long distances along the anterior-posterior (A-P) body axis within precisely positioned longitudinally oriented tracts to facilitate the transmission of information between CNS regions. Despite the widespread distribution and functional importance of these longitudinal tracts, the mechanisms that regulate their formation and projection to poorly characterized synaptic targets remain largely unknown. Nevertheless, recent studies carried out in a variety of invertebrate and vertebrate model systems have begun to elucidate the molecular logic that controls longitudinal axon guidance.

Citing Articles

Computational Generation of Long-range Axonal Morphologies.

Berchet A, Petkantchin R, Markram H, Kanari L Neuroinformatics. 2025; 23(1):3.

PMID: 39792293 PMC: 11723904. DOI: 10.1007/s12021-024-09696-0.

Commissural axon guidance in the developing spinal cord: from Cajal to the present day.

Comer J, Alvarez S, Butler S, Kaltschmidt J Neural Dev. 2019; 14(1):9.

PMID: 31514748 PMC: 6739980. DOI: 10.1186/s13064-019-0133-1.

Roles of axon guidance molecules in neuronal wiring in the developing spinal cord.

Chedotal A Nat Rev Neurosci. 2019; 20(7):380-396.

PMID: 31000796 DOI: 10.1038/s41583-019-0168-7.

Spinal RacGAP α-Chimaerin Is Required to Establish the Midline Barrier for Proper Corticospinal Axon Guidance.

Katori S, Noguchi-Katori Y, Itohara S, Iwasato T J Neurosci. 2017; 37(32):7682-7699.

PMID: 28747385 PMC: 6596649. DOI: 10.1523/JNEUROSCI.3123-16.2017.

K Channel Kv3.4 Is Essential for Axon Growth by Limiting the Influx of Ca into Growth Cones.

Huang C, Lien C, Cheng C, Yen T, Chen C, Tsaur M J Neurosci. 2017; 37(17):4433-4449.

PMID: 28320840 PMC: 6596659. DOI: 10.1523/JNEUROSCI.1076-16.2017.

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