Prion-like Spread of Protein Aggregates in Neurodegeneration

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 2012 May 9

PMID 22566400

Citations 100

Authors

Magdalini Polymenidou

Don W Cleveland

Affiliations

Soon will be listed here.

Abstract

Protein misfolding is common to most neurodegenerative diseases, including Alzheimer's and Parkinson's diseases. Recent work using animal models with intracellular α-synuclein and tau inclusions adds decisively to a growing body of evidence that misfolded protein aggregates can induce a self-perpetuating process that leads to amplification and spreading of pathological protein assemblies. When coupled with the progressive nature of neurodegeneration, recognition of such cell-to-cell aggregate spread suggests a unifying mechanism underlying the pathogenesis of these disorders.

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