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The Role of Vitamin D in Pregnancy and Lactation: Emerging Concepts

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Date 2012 May 5
PMID 22554179
Citations 35
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Abstract

Pregnancy is a critical time in the lifecycle of a woman where she is responsible not only for her own well-being, but also that of her developing fetus, a process that continues during lactation. Until recently, the impact of vitamin D status during this period had not been fully appreciated. Data regarding the importance of vitamin D in health have emerged to challenge traditional dogma, and suggest that vitamin D - through its effect on immune function and surveillance - plays a role beyond calcium and bone metabolism on the health status of both the mother and her fetus. Following birth, this process persists; the lactating mother continues to be the main source of vitamin D for her infant. Thus, during both pregnancy and lactation, maternal deficiency predicts fetal and infant deficiency; the significance of this is just beginning to be understood and will be highlighted in this review.

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References
1.
Brown J, Bianco J, McGrath J, Eyles D . 1,25-dihydroxyvitamin D3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons. Neurosci Lett. 2003; 343(2):139-43. DOI: 10.1016/s0304-3940(03)00303-3. View

2.
Stevenson J, Hillyard C, MacIntyre I, Cooper H, Whitehead M . A physiological role for calcitonin: protection of the maternal skeleton. Lancet. 1979; 2(8146):769-70. DOI: 10.1016/s0140-6736(79)92117-2. View

3.
Hollis B, Wagner C . Assessment of dietary vitamin D requirements during pregnancy and lactation. Am J Clin Nutr. 2004; 79(5):717-26. DOI: 10.1093/ajcn/79.5.717. View

4.
Liu S, Song Y, Ford E, Manson J, Buring J, Ridker P . Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older U.S. women. Diabetes Care. 2005; 28(12):2926-32. DOI: 10.2337/diacare.28.12.2926. View

5.
Brooke O, Brown I, Cleeve H, Sood A . Observations on the vitamin D state of pregnant Asian women in London. Br J Obstet Gynaecol. 1981; 88(1):18-26. DOI: 10.1111/j.1471-0528.1981.tb00931.x. View