Partial Escape of HIV-1 from Cytotoxic T Lymphocytes During Chronic Infection

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2012 May 4

PMID 22553321

Citations 5

Authors

Martha J Lewis

Mirabelle Dagarag

Basim Khan

Ayub Ali

Otto O Yang

Affiliations

Soon will be listed here.

Abstract

Viral mutational escape from CD8(+) cytotoxic T lymphocytes (CTLs) is typically considered to be a dichotomous process and uncommon during chronic HIV-1 infection. Ex vivo passaging of HIV-1 from persons with chronic infection, however, revealed the evolution of many fixed substitutions within and around CTL-targeted regions, with an associated increase in replicative capacity. This indicates an evolution of mutations during chronic HIV-1 infection that trade replicative fitness for incomplete evasion of CTLs, or "partial escape."

Citing Articles

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