Pasteurella Multocida Toxin Interaction with Host Cells: Entry and Cellular Effects

Overview

Journal Curr Top Microbiol Immunol

Specialties Allergy & Immunology
Microbiology

Date 2012 May 4

PMID 22552700

Citations 17

Authors

Brenda A Wilson

Mengfei Ho

Affiliations

Soon will be listed here.

Abstract

The mitogenic dermonecrotic toxin from Pasteurella multocida (PMT) is a 1285-residue multipartite protein that belongs to the A-B family of bacterial protein toxins. Through its G-protein-deamidating activity on the α subunits of heterotrimeric G(q)-, G(i)- and G(12/13)-proteins, PMT potently stimulates downstream mitogenic, calcium, and cytoskeletal signaling pathways. These activities lead to pleiotropic effects in different cell types, which ultimately result in cellular proliferation, while inhibiting cellular differentiation, and account for the myriad of physiological outcomes observed during infection with toxinogenic strains of P. multocida.

Citing Articles

Revealing the lethal effects of toxin on multiple organ systems.

Yuan J, Li J, Du S, Wen Y, Wang Y, Lang Y Front Microbiol. 2024; 15:1459124.

PMID: 39257615 PMC: 11385013. DOI: 10.3389/fmicb.2024.1459124.

CXCL8 Knockout: A Key to Resisting Toxin-Induced Cytotoxicity.

Yuan J, Zhao Q, Li J, Wen Y, Wu R, Zhao S Int J Mol Sci. 2024; 25(10).

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Some Examples of Bacterial Toxins as Tools.

Schmidt G Toxins (Basel). 2024; 16(5).

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Toxinome-the bacterial protein toxin database.

Danov A, Segev O, Bograd A, Ben Eliyahu Y, Dotan N, Kaplan T mBio. 2023; 15(1):e0191123.

PMID: 38117054 PMC: 10790787. DOI: 10.1128/mbio.01911-23.

Genome wide CRISPR screen for Pasteurella multocida toxin (PMT) binding proteins reveals LDL Receptor Related Protein 1 (LRP1) as crucial cellular receptor.

Schoellkopf J, Mueller T, Hippchen L, Mueller T, Reuten R, Backofen R PLoS Pathog. 2022; 18(12):e1010781.

PMID: 36516199 PMC: 9797058. DOI: 10.1371/journal.ppat.1010781.

References

Orth J, Lang S, Preuss I, Milligan G, Aktories K . Action of Pasteurella multocida toxin on Galpha(q) is persistent and independent of interaction with G-protein-coupled receptors. Cell Signal. 2007; 19(10):2174-82. DOI: 10.1016/j.cellsig.2007.06.016. View

Cheville N, Rimler R . A protein toxin from Pasteurella multocida type D causes acute and chronic hepatic toxicity in rats. Vet Pathol. 1989; 26(2):148-57. DOI: 10.1177/030098588902600208. View

Bunemann M, Meyer T, Pott L, Hosey M . Novel inhibition of gbetagamma-activated potassium currents induced by M(2) muscarinic receptors via a pertussis toxin-insensitive pathway. J Biol Chem. 2000; 275(17):12537-45. DOI: 10.1074/jbc.275.17.12537. View

Meyer T, Biewald A, Bender K, Eickel A, Pott L . Depletion of phosphatidylinositol 4,5-bisphosphate by activation of phospholipase C-coupled receptors causes slow inhibition but not desensitization of G protein-gated inward rectifier K+ current in atrial myocytes. J Biol Chem. 2000; 276(8):5650-8. DOI: 10.1074/jbc.M009179200. View

Hoskins I, Thomas L, Lax A . Nasal infection with Pasteurella multocida causes proliferation of bladder epithelium in gnotobiotic pigs. Vet Rec. 1997; 140(1):22. DOI: 10.1136/vr.140.1.22. View

Satomura A, Yanai M, Fujita T, Arashima Y, Kumasaka K, Nakane C . Peritonitis associated with Pasteurella multocida: molecular evidence of zoonotic etiology. Ther Apher Dial. 2010; 14(3):373-6. DOI: 10.1111/j.1744-9987.2009.00788.x. View

Sabri A, Wilson B, Steinberg S . Dual actions of the Galpha(q) agonist Pasteurella multocida toxin to promote cardiomyocyte hypertrophy and enhance apoptosis susceptibility. Circ Res. 2002; 90(8):850-7. PMC: 1866365. DOI: 10.1161/01.res.0000016165.23795.1f. View

Arashima Y, Kumasaka K . Pasteurellosis as zoonosis. Intern Med. 2005; 44(7):692-3. DOI: 10.2169/internalmedicine.44.692. View

Foged N . Pasteurella multocida toxin. The characterisation of the toxin and its significance in the diagnosis and prevention of progressive atrophic rhinitis in pigs. APMIS Suppl. 1992; 25:1-56. View

10.

Klein N, Cunha B . Pasteurella multocida pneumonia. Semin Respir Infect. 1997; 12(1):54-6. View

11.

Kimman T, Lowik C, Thesingh C, Defize P, Kamp E, BIJVOET O . Stimulation of bone resorption by inflamed nasal mucosa, dermonecrotic toxin-containing conditioned medium from Pasteurella multocida, and purified dermonecrotic toxin from P. multocida. Infect Immun. 1987; 55(9):2110-6. PMC: 260664. DOI: 10.1128/iai.55.9.2110-2116.1987. View

12.

Preuss I, Hildebrand D, Orth J, Aktories K, Kubatzky K . Pasteurella multocida toxin is a potent activator of anti-apoptotic signalling pathways. Cell Microbiol. 2010; 12(8):1174-85. DOI: 10.1111/j.1462-5822.2010.01462.x. View

13.

Rutter J, Luther P . Cell culture assay for toxigenic Pasteurella multocida from atrophic rhinitis of pigs. Vet Rec. 1984; 114(16):393-6. DOI: 10.1136/vr.114.16.393. View

14.

Baldwin M, Lakey J, Lax A . Identification and characterization of the Pasteurella multocida toxin translocation domain. Mol Microbiol. 2004; 54(1):239-50. DOI: 10.1111/j.1365-2958.2004.04264.x. View

15.

Oswald E, Sugai M, Labigne A, Wu H, Fiorentini C, Boquet P . Cytotoxic necrotizing factor type 2 produced by virulent Escherichia coli modifies the small GTP-binding proteins Rho involved in assembly of actin stress fibers. Proc Natl Acad Sci U S A. 1994; 91(9):3814-8. PMC: 43672. DOI: 10.1073/pnas.91.9.3814. View

16.

Henderson S, Shah A, Banford K, Howard L . Pig trotters lung--novel domestic transmission of Pasteurella multocida. Clin Med (Lond). 2010; 10(5):517-8. PMC: 4952421. DOI: 10.7861/clinmedicine.10-5-517. View

17.

Brothers M, Ho M, Maharjan R, Clemons N, Bannai Y, Waites M . Membrane interaction of Pasteurella multocida toxin involves sphingomyelin. FEBS J. 2011; 278(23):4633-48. PMC: 3220749. DOI: 10.1111/j.1742-4658.2011.08365.x. View

18.

Migliore E, Serraino C, Brignone C, Ferrigno D, Cardellicchio A, Pomero F . Pasteurella multocida infection in a cirrhotic patient: case report, microbiological aspects and a review of literature. Adv Med Sci. 2009; 54(1):109-12. DOI: 10.2478/v10039-009-0005-8. View

19.

Gwaltney S, Galvin R, Register K, Rimler R, Ackermann M . Effects of Pasteurella multocida toxin on porcine bone marrow cell differentiation into osteoclasts and osteoblasts. Vet Pathol. 1997; 34(5):421-30. DOI: 10.1177/030098589703400506. View

20.

Mullan P, Lax A . Pasteurella multocida toxin stimulates bone resorption by osteoclasts via interaction with osteoblasts. Calcif Tissue Int. 1998; 63(4):340-5. DOI: 10.1007/s002239900537. View