Regeneration of the Periodontium Using Enamel Matrix Derivative in Combination with an Injectable Bone Cement

Overview

Journal Clin Oral Investig

Specialty Dentistry

Date 2012 May 4

PMID 22552596

Citations 13

Authors

Daniel A W Oortgiesen

Gert J Meijer

Antonius L J J Bronckers

X Frank Walboomers

John A Jansen

Affiliations

Soon will be listed here.

Abstract

Objectives: Enamel matrix derivative (EMD) has proven to enhance periodontal regeneration; however, its effect is mainly restricted to the soft periodontal tissues. Therefore, to stimulate not only the soft tissues, but also the hard tissues, in this study EMD is combined with an injectable calcium phosphate cement (CaP; bone graft material). The aim was to evaluate histologically the healing of a macroporous CaP in combination with EMD.

Materials And Methods: Intrabony, three-wall periodontal defects (2 × 2 × 1.7 mm) were created mesial of the first upper molar in 15 rats (30 defects). Defects were randomly treated according to one of the three following strategies: EMD, calcium phosphate cement and EMD, or left empty. The animals were killed after 12 weeks, and retrieved samples were processed for histology and histomorphometry.

Results: Empty defects showed a reparative type of healing without periodontal ligament or bone regeneration. As measured with on a histological grading scale for periodontal regeneration, the experimental groups (EMD and CaP/EMD) scored equally, both threefold higher compared with empty defects. However, most bone formation was measured in the CaP/EMD group; addition of CAP to EMD significantly enhanced bone formation with 50 % compared with EMD alone.

Conclusions: Within the limits of this animal study, the adjunctive use of EMD in combination with an injectable cement, although it did not affect epithelial downgrowth, appeared to be a promising treatment modality for regeneration of bone and ligament tissues in the periodontium.

Clinical Relevance: The adjunctive use of EMD in combination with an injectable cement appears to be a promising treatment modality for regeneration of the bone and ligament tissues in the periodontium.

Citing Articles

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Animal models for testing biomaterials in periodontal regeneration.

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Bone Grafts in Dental Medicine: An Overview of Autografts, Allografts and Synthetic Materials.

Ferraz M Materials (Basel). 2023; 16(11).

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Synthetic Injectable Biomaterials for Alveolar Bone Regeneration in Animal and Human Studies.

Tomas M, candrlic M, Juzbasic M, Ivanisevic Z, Matijevic N, Vcev A Materials (Basel). 2021; 14(11).

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Bioactive Materials for Soft Tissue Repair.

Mazzoni E, Iaquinta M, Lanzillotti C, Mazziotta C, Maritati M, Montesi M Front Bioeng Biotechnol. 2021; 9:613787.

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