Efficacy of a Proapoptotic Peptide Towards Cancer Cells

Overview

Journal In Vivo

Specialty Oncology

Date 2012 Apr 24

PMID 22523294

Citations 7

Authors

Clara E Jakel

Karoline Meschenmoser

Young Kim

Hans Weiher

Ingo G H Schmidt-Wolf

Affiliations

Soon will be listed here.

Abstract

Background: Conventional cancer therapies are associated with severe side-effects and the development of drug resistance. Therefore, new strategies to specifically target tumor cells leaving healthy tissue unaffected are of great interest.

Materials And Methods: On this respect, we tested the antimicrobial peptide (KLAKLAK)(2).

Results: This peptide exhibits cytotoxicity against human breast cancer and other tumor cells, while healthy cells remain unaffected. Moreover, treatment with this cationic amphipathic peptide results in slower tumor growth and longer overall survival in vivo.

Conclusion: Our data suggest a potential use of (KLAKLAK)(2) peptide for patients with breast and other types of cancer.

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