Gasotransmitters: Novel Regulators of Epithelial Na(+) Transport?

Overview

Journal Front Physiol

Date 2012 Apr 18

PMID 22509167

Citations 10

Authors

Mike Althaus

Affiliations

Soon will be listed here.

Abstract

The vectorial transport of Na(+) across epithelia is crucial for the maintenance of Na(+) and water homeostasis in organs such as the kidneys, lung, or intestine. Dysregulated Na(+) transport processes are associated with various human diseases such as hypertension, the salt-wasting syndrome pseudohypoaldosteronism type 1, pulmonary edema, cystic fibrosis, or intestinal disorders, which indicate that a precise regulation of epithelial Na(+) transport is essential. Novel regulatory signaling molecules are gasotransmitters. There are currently three known gasotransmitters: nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H(2)S). These molecules are endogenously produced in mammalian cells by specific enzymes and have been shown to regulate various physiological processes. There is a growing body of evidence which indicates that gasotransmitters may also regulate Na(+) transport across epithelia. This review will summarize the available data concerning NO, CO, and H(2)S dependent regulation of epithelial Na(+) transport processes and will discuss whether or not these mediators can be considered as true physiological regulators of epithelial Na(+) transport biology.

Citing Articles

Epithelial Na Channels Function as Extracellular Sensors.

Kashlan O, Wang X, Sheng S, Kleyman T Compr Physiol. 2024; 14(2):1-41.

PMID: 39109974 PMC: 11309579. DOI: 10.1002/cphy.c230015.

Inducible Nitric Oxide Synthase/Nitric Oxide System as a Biomarker for Stress and Ease Response in Fish: Implication on Na Homeostasis During Hypoxia.

Peter M, Gayathry R, Peter V Front Physiol. 2022; 13:821300.

PMID: 35655956 PMC: 9152262. DOI: 10.3389/fphys.2022.821300.

Adaptation and Probiotic Potential of Lactobacilli, Isolated from the Oral Cavity and Intestines of Healthy People.

Chervinets Y, Chervinets V, Shenderov B, Belyaeva E, Troshin A, Lebedev S Probiotics Antimicrob Proteins. 2017; 10(1):22-33.

PMID: 29164486 DOI: 10.1007/s12602-017-9348-9.

Neuromodulatory effects and targets of the SCFAs and gasotransmitters produced by the human symbiotic microbiota.

Oleskin A, Shenderov B Microb Ecol Health Dis. 2016; 27:30971.

PMID: 27389418 PMC: 4937721. DOI: 10.3402/mehd.v27.30971.

Epithelial Electrolyte Transport Physiology and the Gasotransmitter Hydrogen Sulfide.

Pouokam E, Althaus M Oxid Med Cell Longev. 2016; 2016:4723416.

PMID: 26904165 PMC: 4745330. DOI: 10.1155/2016/4723416.

References

Coon S, Shao G, Wisel S, Vulaupalli R, Sundaram U . Mechanism of regulation of rabbit intestinal villus cell brush border membrane Na/H exchange by nitric oxide. Am J Physiol Gastrointest Liver Physiol. 2007; 292(2):G475-81. DOI: 10.1152/ajpgi.00263.2005. View

Wang S, Publicover S, Gu Y . An oxygen-sensitive mechanism in regulation of epithelial sodium channel. Proc Natl Acad Sci U S A. 2009; 106(8):2957-62. PMC: 2650320. DOI: 10.1073/pnas.0809100106. View

Cabral P, Garvin J . Luminal flow regulates NO and O2(-) along the nephron. Am J Physiol Renal Physiol. 2011; 300(5):F1047-53. PMC: 3094045. DOI: 10.1152/ajprenal.00724.2010. View

Pittet J, Lu L, Morris D, Modelska K, Welch W, Carey H . Reactive nitrogen species inhibit alveolar epithelial fluid transport after hemorrhagic shock in rats. J Immunol. 2001; 166(10):6301-10. DOI: 10.4049/jimmunol.166.10.6301. View

Izzo A, Mascolo N, Capasso F . Nitric oxide as a modulator of intestinal water and electrolyte transport. Dig Dis Sci. 1998; 43(8):1605-20. DOI: 10.1023/a:1018887525293. View

Texereau J, Fajac I, Hubert D, Coste J, Dusser D, Bienvenu T . Reduced exhaled NO is related to impaired nasal potential difference in patients with cystic fibrosis. Vascul Pharmacol. 2005; 43(6):385-9. DOI: 10.1016/j.vph.2005.08.004. View

Jain L, Chen X, Brown L, Eaton D . Nitric oxide inhibits lung sodium transport through a cGMP-mediated inhibition of epithelial cation channels. Am J Physiol. 1998; 274(4):L475-84. DOI: 10.1152/ajplung.1998.274.4.L475. View

Grandes S, Gallego M, RIESCO A, Lopez Farre A, Millas I, Casado S . Mechanisms of renal effects of different agents stimulating production of cGMP. Am J Physiol. 1991; 261(4 Pt 2):H1109-14. DOI: 10.1152/ajpheart.1991.261.4.H1109. View

Jin X, McGrath H, Gildea J, Siragy H, Felder R, Carey R . Renal interstitial guanosine cyclic 3', 5'-monophosphate mediates pressure-natriuresis via protein kinase G. Hypertension. 2004; 43(5):1133-9. DOI: 10.1161/01.HYP.0000123574.60586.7d. View

10.

Garvin J, Herrera M, Ortiz P . Regulation of renal NaCl transport by nitric oxide, endothelin, and ATP: clinical implications. Annu Rev Physiol. 2010; 73:359-76. DOI: 10.1146/annurev-physiol-012110-142247. View

11.

Suzuki Y, Lu Q, Xu D, Szabo C, Hasko G, Deitch E . Na+,K+-ATPase activity is inhibited in cultured intestinal epithelial cells by endotoxin or nitric oxide. Int J Mol Med. 2005; 15(5):871-7. View

12.

Sasaki S, Siragy H, Gildea J, Felder R, Carey R . Production and role of extracellular guanosine cyclic 3', 5' monophosphate in sodium uptake in human proximal tubule cells. Hypertension. 2004; 43(2):286-91. DOI: 10.1161/01.HYP.0000112421.18551.1e. View

13.

Lindemann H, Klimek T, Glanz H, Weber W . Nitric oxide has no beneficial effects on ion transport defects in cystic fibrosis human nasal epithelium. Pflugers Arch. 2001; 441(1):133-7. DOI: 10.1007/s004240000394. View

14.

Olson K, Whitfield N, Bearden S, Leger J, Nilson E, Gao Y . Hypoxic pulmonary vasodilation: a paradigm shift with a hydrogen sulfide mechanism. Am J Physiol Regul Integr Comp Physiol. 2009; 298(1):R51-60. PMC: 2806212. DOI: 10.1152/ajpregu.00576.2009. View

15.

Zhao W, Ndisang J, Wang R . Modulation of endogenous production of H2S in rat tissues. Can J Physiol Pharmacol. 2003; 81(9):848-53. DOI: 10.1139/y03-077. View

16.

Steidle J, Diener M . Effects of carbon monoxide on ion transport across rat distal colon. Am J Physiol Gastrointest Liver Physiol. 2010; 300(2):G207-16. DOI: 10.1152/ajpgi.00407.2010. View

17.

Ma X, Sayed N, Beuve A, van den Akker F . NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism. EMBO J. 2007; 26(2):578-88. PMC: 1783457. DOI: 10.1038/sj.emboj.7601521. View

18.

Yu L, Bao H, Self J, Eaton D, Helms M . Aldosterone-induced increases in superoxide production counters nitric oxide inhibition of epithelial Na channel activity in A6 distal nephron cells. Am J Physiol Renal Physiol. 2007; 293(5):F1666-77. DOI: 10.1152/ajprenal.00444.2006. View

19.

Ermert M, Ruppert C, Gunther A, Duncker H, Seeger W, Ermert L . Cell-specific nitric oxide synthase-isoenzyme expression and regulation in response to endotoxin in intact rat lungs. Lab Invest. 2002; 82(4):425-41. PMC: 7102244. DOI: 10.1038/labinvest.3780436. View

20.

Althaus M, Fronius M, Buchackert Y, Vadasz I, Clauss W, Seeger W . Carbon monoxide rapidly impairs alveolar fluid clearance by inhibiting epithelial sodium channels. Am J Respir Cell Mol Biol. 2009; 41(6):639-50. DOI: 10.1165/rcmb.2008-0458OC. View