Aging Phenotypes of Common Marmosets (Callithrix Jacchus)

Overview

Journal J Aging Res

Publisher Wiley

Specialty Geriatrics

Date 2012 Apr 17

PMID 22506113

Citations 62

Authors

Corinna N Ross

Kenneth Davis

Georgina Dobek

Suzette D Tardif

Affiliations

Soon will be listed here.

Abstract

Characterizing the phenotypic changes associated with aging in a short-lived primate is necessary in order to develop better translational models for human health, aging, and disease research. A population of conventionally housed marmoset monkeys was assessed to determine if phenotypes of body composition, hematology, and morphometrical measures were associated with age or risk of death. We found that the cause of mortality in older marmosets was more likely to be due to cardiac and chronic kidney disease than in younger marmosets. Older marmosets have decreased fat mass, morphometric measures, and serum albumin. Older marmosets are more likely to show a modified posture while at rest and this modified posture was significantly associated with an increased risk of imminent death. These assessments provide an initial definition of aged health in marmosets and a base for future translational aging research with this species.

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