Diminished Adult Neurogenesis in the Marmoset Brain Precedes Old Age

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2007 Oct 18

PMID 17940008

Citations 109

Authors

Benedetta Leuner

Yevgenia Kozorovitskiy

Charles G Gross

Elizabeth Gould

Affiliations

Soon will be listed here.

Abstract

With aging there is a decline in the number of newly generated neurons in the dentate gyrus of the hippocampus. In rodents and tree shrews, this age-related decrease in neurogenesis is evident long before the animals become aged. No previous studies have investigated whether primates exhibit a similar decline in hippocampal neurogenesis with aging. To investigate this possibility, young to middle aged adult common marmosets (Callithrix jacchus) were injected with BrdU and perfused 3 weeks later. The number of newly generated cells in the subgranular zone/granule cell layer of the dentate gyrus was significantly lower in older animals and decreased linearly with age. A similar age-related decline in new cells was observed in the subventricular zone but not in the hilar region of the dentate gyrus. These data demonstrate that a substantial decrease in neurogenesis occurs before the onset of old age in the adult marmoset brain, suggesting the possibility that similar alterations occur in the human brain.

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