Blood Levels of Macrophage Migration Inhibitory Factor After Successful Resuscitation from Cardiac Arrest

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2012 Apr 17

PMID 22506003

Citations 6

Authors

Christian Stoppe

Michael Fries

Rolf Rossaint

Gerrit Grieb

Mark Coburn

David Simons

David Brucken

Jurgen Bernhagen

Norbert Pallua

Steffen Rex

Affiliations

Soon will be listed here.

Abstract

Introduction: Ischemia-reperfusion injury following cardiopulmonary resuscitation (CPR) is associated with a systemic inflammatory response, resulting in post-resuscitation disease. In the present study we investigated the response of the pleiotropic inflammatory cytokine macrophage migration inhibitory factor (MIF) to CPR in patients admitted to the hospital after out-of-hospital cardiac arrest (OHCA). To describe the magnitude of MIF release, we compared the blood levels from CPR patients with those obtained in healthy volunteers and with an aged- and gender-matched group of patients undergoing cardiac surgery with the use of extracorporeal circulation.

Methods: Blood samples of 17 patients with return of spontaneous circulation (ROSC) after OHCA were obtained upon admission to the intensive care unit, and 6, 12, 24, 72 and 96 h later. Arrest and treatment related data were documented according to the Utstein style.

Results: In patients after ROSC, MIF levels at admission (475.2±157.8 ng/ml) were significantly higher than in healthy volunteers (12.5±16.9 ng/ml, p<0.007) and in patients after cardiac surgery (78.2±41.6 ng/ml, p<0.007). Six hours after admission, MIF levels were decreased by more than 50% (150.5±127.2 ng/ml, p<0.007), but were not further reduced in the subsequent time course and remained significantly higher than the values observed during the ICU stay of cardiac surgical patients. In this small group of patients, MIF levels could not discriminate between survivors and non-survivors and were not affected by treatment with mild therapeutic hypothermia.

Conclusion: MIF shows a rapid and pronounced increase following CPR, hence allowing a very early assessment of the inflammatory response. Further studies are warranted in larger patient groups to determine the prognostic significance of MIF.

Trial Registration: ClinicalTrials.gov NCT01412619.

Citing Articles

Brain Kynurenine Pathway and Functional Outcome of Rats Resuscitated From Cardiac Arrest.

Lucchetti J, Fumagalli F, Olivari D, Affatato R, Fracasso C, De Giorgio D J Am Heart Assoc. 2021; 10(23):e021071.

PMID: 34816736 PMC: 9075408. DOI: 10.1161/JAHA.121.021071.

Macrophage-specific protein perforin-2 is associated with poor neurological recovery and reduced survival after sudden cardiac arrest.

Kattel S, Bhatt H, Xu S, Gurung S, Pokharel S, Sharma U Resuscitation. 2020; 155:180-188.

PMID: 32828820 PMC: 8007065. DOI: 10.1016/j.resuscitation.2020.08.005.

Sub-anesthetic Xenon Increases Erythropoietin Levels in Humans: A Randomized Controlled Trial.

Stoppe C, Ney J, Brenke M, Goetzenich A, Emontzpohl C, Schalte G Sports Med. 2016; 46(11):1753-1766.

PMID: 26939898 DOI: 10.1007/s40279-016-0505-1.

Filtration of Macrophage Migration Inhibitory Factor (MIF) in Patients with End Stage Renal Disease Undergoing Hemodialysis.

Luedike P, Rammos C, Pohl J, Heisler M, Totzeck M, Kleophas W PLoS One. 2015; 10(10):e0140215.

PMID: 26485680 PMC: 4617461. DOI: 10.1371/journal.pone.0140215.

Interaction of MIF Family Proteins in Myocardial Ischemia/Reperfusion Damage and Their Influence on Clinical Outcome of Cardiac Surgery Patients.

Stoppe C, Rex S, Goetzenich A, Kraemer S, Emontzpohl C, Soppert J Antioxid Redox Signal. 2015; 23(11):865-79.

PMID: 26234719 PMC: 4615780. DOI: 10.1089/ars.2014.6243.

References

Yende S, Angus D, Kong L, Kellum J, Weissfeld L, Ferrell R . The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia. FASEB J. 2009; 23(8):2403-11. PMC: 2717777. DOI: 10.1096/fj.09-129445. View

Grieb G, Simons D, Piatkowski A, Bernhagen J, Steffens G, Pallua N . Macrophage migration inhibitory factor-A potential diagnostic tool in severe burn injuries?. Burns. 2009; 36(3):335-42. DOI: 10.1016/j.burns.2009.04.019. View

Bernhagen J, Krohn R, Lue H, Gregory J, Zernecke A, Koenen R . MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med. 2007; 13(5):587-96. DOI: 10.1038/nm1567. View

Calandra T, Bernhagen J, Metz C, SPIEGEL L, Bacher M, Donnelly T . MIF as a glucocorticoid-induced modulator of cytokine production. Nature. 1995; 377(6544):68-71. DOI: 10.1038/377068a0. View

Calandra T, Echtenacher B, ROY D, Pugin J, Metz C, Hultner L . Protection from septic shock by neutralization of macrophage migration inhibitory factor. Nat Med. 2000; 6(2):164-70. DOI: 10.1038/72262. View

Gando S, Nanzaki S, Morimoto Y, Kobayashi S, Kemmotsu O . Out-of-hospital cardiac arrest increases soluble vascular endothelial adhesion molecules and neutrophil elastase associated with endothelial injury. Intensive Care Med. 2000; 26(1):38-44. DOI: 10.1007/s001340050009. View

Kim J, Hyun S, Hwang S, Jung Y, Shin J, Lim Y . Hormonal responses upon return of spontaneous circulation after cardiac arrest: a retrospective cohort study. Crit Care. 2011; 15(1):R53. PMC: 3221984. DOI: 10.1186/cc10019. View

Fries M, Kunz D, Gressner A, Rossaint R, Kuhlen R . Procalcitonin serum levels after out-of-hospital cardiac arrest. Resuscitation. 2003; 59(1):105-9. DOI: 10.1016/s0300-9572(03)00164-3. View

Calandra T, Bernhagen J, Mitchell R, Bucala R . The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor. J Exp Med. 1994; 179(6):1895-902. PMC: 2191507. DOI: 10.1084/jem.179.6.1895. View

10.

Laver S, Farrow C, Turner D, Nolan J . Mode of death after admission to an intensive care unit following cardiac arrest. Intensive Care Med. 2004; 30(11):2126-8. DOI: 10.1007/s00134-004-2425-z. View

11.

Sakuragi T, Lin X, Metz C, Ojamaa K, Kohn N, Al-Abed Y . Lung-derived macrophage migration inhibitory factor in sepsis induces cardio-circulatory depression. Surg Infect (Larchmt). 2007; 8(1):29-40. PMC: 3104265. DOI: 10.1089/sur.2006.031. View

12.

Laurent I, Monchi M, Chiche J, Joly L, Spaulding C, Bourgeois B . Reversible myocardial dysfunction in survivors of out-of-hospital cardiac arrest. J Am Coll Cardiol. 2002; 40(12):2110-6. DOI: 10.1016/s0735-1097(02)02594-9. View

13.

Adrie C, Adib-Conquy M, Laurent I, Monchi M, Vinsonneau C, Fitting C . Successful cardiopulmonary resuscitation after cardiac arrest as a "sepsis-like" syndrome. Circulation. 2002; 106(5):562-8. DOI: 10.1161/01.cir.0000023891.80661.ad. View

14.

Fries M, Stoppe C, Brucken D, Rossaint R, Kuhlen R . Influence of mild therapeutic hypothermia on the inflammatory response after successful resuscitation from cardiac arrest. J Crit Care. 2009; 24(3):453-7. DOI: 10.1016/j.jcrc.2008.10.012. View

15.

Neumar R, Nolan J, Adrie C, Aibiki M, Berg R, Bottiger B . Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment, and prognostication. A consensus statement from the International Liaison Committee on Resuscitation (American Heart Association, Australian and New Zealand Council on.... Circulation. 2008; 118(23):2452-83. DOI: 10.1161/CIRCULATIONAHA.108.190652. View

16.

Morand E, Leech M, Bernhagen J . MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis. Nat Rev Drug Discov. 2006; 5(5):399-410. DOI: 10.1038/nrd2029. View

17.

Trzeciak S, Jones A, Kilgannon J, Milcarek B, Hunter K, Shapiro N . Significance of arterial hypotension after resuscitation from cardiac arrest. Crit Care Med. 2009; 37(11):2895-903. DOI: 10.1097/ccm.0b013e3181b01d8c. View

18.

Gando S, Nishihira J, Kobayashi S, Morimoto Y, Nanzaki S, Kemmotsu O . Macrophage migration inhibitory factor is a critical mediator of systemic inflammatory response syndrome. Intensive Care Med. 2001; 27(7):1187-93. DOI: 10.1007/s001340000818. View

19.

Merk M, Zierow S, Leng L, Das R, Du X, Schulte W . The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF). Proc Natl Acad Sci U S A. 2011; 108(34):E577-85. PMC: 3161582. DOI: 10.1073/pnas.1102941108. View

20.

Derwall M, Stoppe C, Brucken D, Rossaint R, Fries M . Changes in S-100 protein serum levels in survivors of out-of-hospital cardiac arrest treated with mild therapeutic hypothermia: a prospective, observational study. Crit Care. 2009; 13(2):R58. PMC: 2689505. DOI: 10.1186/cc7785. View