The Context of Gene Expression Regulation

Overview

Journal F1000 Biol Rep

Specialty Biology

Date 2012 Apr 14

PMID 22500194

Citations 12

Authors

Johan H Gibcus

Job Dekker

Affiliations

Soon will be listed here.

Abstract

Recent advances in sequencing technologies have uncovered a world of RNAs that do not code for proteins, known as non-protein coding RNAs, that play important roles in gene regulation. Along with histone modifications and transcription factors, non-coding RNA is part of a layer of transcriptional control on top of the DNA code. This layer of components and their interactions specifically enables (or disables) the modulation of three-dimensional folding of chromatin to create a context for transcriptional regulation that underlies cell-specific transcription. In this perspective, we propose a structural and functional hierarchy, in which the DNA code, proteins and non-coding RNAs act as context creators to fold chromosomes and regulate genes.

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