The Local Inflammatory Responses to Infection of the Peritoneal Cavity in Humans: Their Regulation by Cytokines, Macrophages, and Other Leukocytes

Overview

Journal Mediators Inflamm

Publisher Wiley

Specialties Biochemistry
Pathology

Date 2012 Apr 7

PMID 22481867

Citations 22

Authors

Marien Willem Johan Adriaan Fieren

Affiliations

Soon will be listed here.

Abstract

Studies on infection-induced inflammatory reactions in humans rely largely on findings in the blood compartment. Peritoneal leukocytes from patients treated with peritoneal dialysis offer a unique opportunity to study in humans the inflammatory responses taking place at the site of infection. Compared with peritoneal macrophages (pMϕ) from uninfected patients, pMϕ from infected patients display ex vivo an upregulation and downregulation of proinflammatory and anti-inflammatory mediators, respectively. Pro-IL-1β processing and secretion rather than synthesis proves to be increased in pMϕ from infectious peritonitis suggesting up-regulation of caspase-1 in vivo. A crosstalk between pMϕ, γδ T cells, and neutrophils has been found to be involved in augmented TNFα expression and production during infection. The recent finding in experimental studies that alternatively activated macrophages (Mϕ2) increase by proliferation rather than recruitment may have significant implications for the understanding and treatment of chronic inflammatory conditions such as encapsulating peritoneal sclerosis (EPS).

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References

Stables M, Newson J, Ayoub S, Brown J, Hyams C, Gilroy D . Priming innate immune responses to infection by cyclooxygenase inhibition kills antibiotic-susceptible and -resistant bacteria. Blood. 2010; 116(16):2950-9. PMC: 5362071. DOI: 10.1182/blood-2010-05-284844. View

Fadok V, Bratton D, Konowal A, Freed P, Westcott J, Henson P . Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. J Clin Invest. 1998; 101(4):890-8. PMC: 508637. DOI: 10.1172/JCI1112. View

Gordon S . The macrophage: past, present and future. Eur J Immunol. 2007; 37 Suppl 1:S9-17. DOI: 10.1002/eji.200737638. View

Geissmann F, Jung S, Littman D . Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity. 2003; 19(1):71-82. DOI: 10.1016/s1074-7613(03)00174-2. View

Fieren M, van den Bemd G, Ben-Efraim S, Bonta I . Prostaglandin E2 inhibits the release of tumor necrosis factor-alpha, rather than interleukin 1 beta, from human macrophages. Immunol Lett. 1992; 31(1):85-90. DOI: 10.1016/0165-2478(92)90015-g. View

Witowski J, Jorres A, Coles G, Williams J, Topley N . Superinduction of IL-6 synthesis in human peritoneal mesothelial cells is related to the induction and stabilization of IL-6 mRNA. Kidney Int. 1996; 50(4):1212-23. DOI: 10.1038/ki.1996.430. View

Bellon T, Martinez V, Lucendo B, Peso G, Castro M, Aroeira L . Alternative activation of macrophages in human peritoneum: implications for peritoneal fibrosis. Nephrol Dial Transplant. 2011; 26(9):2995-3005. DOI: 10.1093/ndt/gfq771. View

Betjes M, Tuk C, Struijk D, Krediet R, Arisz L, Beelen R . Antigen-presenting capacity of macrophages and dendritic cells in the peritoneal cavity of patients treated with peritoneal dialysis. Clin Exp Immunol. 1993; 94(2):377-84. PMC: 1534228. DOI: 10.1111/j.1365-2249.1993.tb03460.x. View

Dasgupta M, Larabie M, Halloran P . Interferon-gamma levels in peritoneal dialysis effluents: relation to peritonitis. Kidney Int. 1994; 46(2):475-81. DOI: 10.1038/ki.1994.297. View

10.

Bonta I, Adolfs M, Fieren M . Cyclic AMP levels and their regulation by prostaglandins in peritoneal macrophages of rats and humans. Int J Immunopharmacol. 1984; 6(6):547-55. DOI: 10.1016/0192-0561(84)90064-x. View

11.

Fieren M, van den Bemd G, Bonta I . Peritoneal macrophages from patients on continuous ambulatory peritoneal dialysis show a differential secretion of prostanoids and interleukin-1 beta. Prostaglandins Leukot Essent Fatty Acids. 1992; 47(1):23-8. DOI: 10.1016/0952-3278(92)90181-h. View

12.

Fieren M, van den Bemd G, Bonta I . Endotoxin-stimulated peritoneal macrophages obtained from continuous ambulatory peritoneal dialysis patients show an increased capacity to release interleukin-1 beta in vitro during infectious peritonitis. Eur J Clin Invest. 1990; 20(4):453-7. DOI: 10.1111/j.1365-2362.1990.tb01883.x. View

13.

Xu W, Schlagwein N, Roos A, van den Berg T, Daha M, van Kooten C . Human peritoneal macrophages show functional characteristics of M-CSF-driven anti-inflammatory type 2 macrophages. Eur J Immunol. 2007; 37(6):1594-9. DOI: 10.1002/eji.200737042. View

14.

Scotton C, Martinez F, Smelt M, Sironi M, Locati M, Mantovani A . Transcriptional profiling reveals complex regulation of the monocyte IL-1 beta system by IL-13. J Immunol. 2005; 174(2):834-45. DOI: 10.4049/jimmunol.174.2.834. View

15.

Topley N, MacKenzie R, Williams J . Macrophages and mesothelial cells in bacterial peritonitis. Immunobiology. 1996; 195(4-5):563-73. DOI: 10.1016/S0171-2985(96)80022-2. View

16.

Goldstein C, Bomalaski J, Zurier R, Neilson E, Douglas S . Analysis of peritoneal macrophages in continuous ambulatory peritoneal dialysis patients. Kidney Int. 1984; 26(5):733-40. DOI: 10.1038/ki.1984.209. View

17.

Maddox Y, Foegh M, Zeligs B, Zmudka M, BELLANTI J, Ramwell P . A routine source of human peritoneal macrophages. Scand J Immunol. 1984; 19(1):23-9. DOI: 10.1111/j.1365-3083.1984.tb00896.x. View

18.

Brauner A, Hylander B, Wretlind B . Interleukin-6 and interleukin-8 in dialysate and serum from patients on continuous ambulatory peritoneal dialysis. Am J Kidney Dis. 1993; 22(3):430-5. DOI: 10.1016/s0272-6386(12)70147-6. View

19.

Braun N, Fritz P, Biegger D, Kimmel M, Reimold F, Ulmer C . Difference in the expression of hormone receptors and fibrotic markers in the human peritoneum--implications for therapeutic targets to prevent encapsulating peritoneal sclerosis. Perit Dial Int. 2011; 31(3):291-300. DOI: 10.3747/pdi.2010.00118. View

20.

Fieren M . Mechanisms regulating cytokine release from peritoneal macrophages during continuous ambulatory peritoneal dialysis. Blood Purif. 1996; 14(2):179-87. DOI: 10.1159/000170261. View