Recent Changes in the Clinicopathologic Features of Korean Men with Prostate Cancer: a Comparison with Western Populations

Overview

Journal Yonsei Med J

Specialty General Medicine

Date 2012 Apr 6

PMID 22476998

Citations 19

Authors

Seok-Soo Byun

Sangchul Lee

Sang Eun Lee

Eunsik Lee

Seong Il Seo

Hyun Moo Lee

Han Yong Choi

Cheryn Song

Hanjong Ahn

Young Deuk Choi

Jin Seon Cho

Affiliations

Soon will be listed here.

Abstract

Purpose: The aim of this study was to evaluate the recent changes in the clinicopathologic features of prostate cancer in Korea and to compare these features with those of Western populations.

Materials And Methods: We retrospectively reviewed the data of 1582 men undergoing radical prostatectomy for clinically localized prostate cancer between 1995 and 2007 at 10 institutions in Korea for comparison with Western studies. The patients were divided into two groups in order to evaluate the recent clinicopathological changes in prostate cancer: Group 1 had surgery between 1995 and 2003 (n=280) and Group 2 had surgery between 2004 and 2007 (n=1302). The mean follow-up period was 24 months.

Results: Group 1 had a higher prostate-specific antigen level than Group 2 (10.0 ng/mL vs. 7.5 ng/mL, respectively; p<0.001) and a lower proportion of biopsy Gleason scores ≤6 (35.0% vs. 48.1%, respectively; p<0.001). The proportion of patients with clinical T1 stage was higher in Group 2 than in Group 1. Group 1 had a lower proportion of organ-confined disease (59.6% vs. 68.6%; p<0.001) and a lower proportion of Gleason scores ≤6 (21.3% vs. 33.0%; p<0.001), compared to Group 2. However, the relatively higher proportion of pathologic Gleason scores ≤6 in Group 2 was still lower than those of Western men, even though the proportion of organ-confined disease reached to that of Western series.

Conclusion: Korean men with prostate cancer currently present better clinicopathologic parameters. However, in comparison, Korean men still show relatively worse pathologic Gleason scores than Western men.

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References

van Houten M, Gooren L . Differences in reproductive endocrinology between Asian men and Caucasian men--a literature review. Asian J Androl. 2001; 2(1):13-20. View

Kim K, Chang H, Cho Y, Youn T, Chung W, Chae I . Current status and characteristics of hypertension control in community resident elderly Korean people: data from a Korean longitudinal study on health and aging (KLoSHa study). Hypertens Res. 2008; 31(1):97-105. DOI: 10.1291/hypres.31.97. View

Song C, Ro J, Lee M, Hong S, Chung B, Choi H . Prostate cancer in Korean men exhibits poor differentiation and is adversely related to prognosis after radical prostatectomy. Urology. 2006; 68(4):820-4. DOI: 10.1016/j.urology.2006.04.029. View

Roehl K, Han M, Ramos C, Antenor J, Catalona W . Cancer progression and survival rates following anatomical radical retropubic prostatectomy in 3,478 consecutive patients: long-term results. J Urol. 2004; 172(3):910-4. DOI: 10.1097/01.ju.0000134888.22332.bb. View

Seo H, Chung M, Ryu S, Lee K . Detection rate of prostate cancer according to prostate-specific antigen and digital rectal examination in Korean men: a nationwide multicenter study. Urology. 2007; 70(6):1109-12. DOI: 10.1016/j.urology.2007.07.052. View

Schroeck F, Aronson W, Presti Jr J, Terris M, Kane C, Amling C . Do nomograms predict aggressive recurrence after radical prostatectomy more accurately than biochemical recurrence alone?. BJU Int. 2008; 103(5):603-8. PMC: 2753544. DOI: 10.1111/j.1464-410X.2008.08118.x. View

Epstein J, Allsbrook Jr W, Amin M, Egevad L . The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma. Am J Surg Pathol. 2005; 29(9):1228-42. DOI: 10.1097/01.pas.0000173646.99337.b1. View

Hsing A, Chu L, Stanczyk F . Androgen and prostate cancer: is the hypothesis dead?. Cancer Epidemiol Biomarkers Prev. 2008; 17(10):2525-30. DOI: 10.1158/1055-9965.EPI-08-0448. View

Grossfeld G, Latini D, Downs T, Lubeck D, Mehta S, Carroll P . Is ethnicity an independent predictor of prostate cancer recurrence after radical prostatectomy?. J Urol. 2002; 168(6):2510-5. DOI: 10.1016/S0022-5347(05)64179-1. View

10.

Hoffman M, DeWolf W, Morgentaler A . Is low serum free testosterone a marker for high grade prostate cancer?. J Urol. 2000; 163(3):824-7. View

11.

Song C, Ahn H, Lee M, Park J, Kwon T, Kim H . Mass screening for prostate cancer in Korea: a population based study. J Urol. 2008; 180(5):1949-52. DOI: 10.1016/j.juro.2008.07.041. View

12.

Cohen J, Schoenbach V, Kaufman J, Talcott J, Schenck A, Peacock S . Racial differences in clinical progression among Medicare recipients after treatment for localized prostate cancer (United States). Cancer Causes Control. 2006; 17(6):803-11. DOI: 10.1007/s10552-006-0017-7. View

13.

Hernandez D, Nielsen M, Han M, Partin A . Contemporary evaluation of the D'amico risk classification of prostate cancer. Urology. 2007; 70(5):931-5. DOI: 10.1016/j.urology.2007.08.055. View

14.

Godley P, Schenck A, Ahinee Amamoo M, Schoenbach V, Peacock S, Manning M . Racial differences in mortality among Medicare recipients after treatment for localized prostate cancer. J Natl Cancer Inst. 2003; 95(22):1702-10. DOI: 10.1093/jnci/djg094. View

15.

Wu A, Whittemore A, Kolonel L, Stanczyk F, John E, Gallagher R . Lifestyle determinants of 5alpha-reductase metabolites in older African-American, white, and Asian-American men. Cancer Epidemiol Biomarkers Prev. 2001; 10(5):533-8. View

16.

Yu H, Harris R, Gao Y, Gao R, Wynder E . Comparative epidemiology of cancers of the colon, rectum, prostate and breast in Shanghai, China versus the United States. Int J Epidemiol. 1991; 20(1):76-81. DOI: 10.1093/ije/20.1.76. View

17.

Freedland S, Amling C, Dorey F, Kane C, Presti Jr J, Terris M . Race as an outcome predictor after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database. Urology. 2002; 60(4):670-4. DOI: 10.1016/s0090-4295(02)01847-2. View

18.

Freedland S, Sutter M, Dorey F, Aronson W . Defining the ideal cutpoint for determining PSA recurrence after radical prostatectomy. Prostate-specific antigen. Urology. 2003; 61(2):365-9. DOI: 10.1016/s0090-4295(02)02268-9. View

19.

Parkin D, Bray F, Ferlay J, Pisani P . Global cancer statistics, 2002. CA Cancer J Clin. 2005; 55(2):74-108. DOI: 10.3322/canjclin.55.2.74. View

20.

Capitanio U, Karakiewicz P, Jeldres C, Briganti A, Gallina A, Suardi N . The probability of Gleason score upgrading between biopsy and radical prostatectomy can be accurately predicted. Int J Urol. 2009; 16(5):526-9. DOI: 10.1111/j.1442-2042.2009.02270.x. View