Cathodal Stimulation of Human MT+ Leads to Elevated FMRI Signal: a TDCS-fMRI Study

Overview

Journal Restor Neurol Neurosci

Publisher Sage Publications

Specialty Neurology

Date 2012 Apr 6

PMID 22475855

Citations 21

Authors

Andrea Antal

Gyula Kovacs

Leila Chaieb

Csaba Cziraki

Walter Paulus

Mark W Greenlee

Affiliations

Soon will be listed here.

Abstract

Purpose: Transcranial direct current stimulation (tDCS) was reintroduced about a decade ago as a tool for inducing long-lasting changes in cortical excitability. Recently it has been shown that both motor and cognitive functions can be influenced by tDCS. Here, we tested the effect of tDCS on the blood-oxygen level dependent (BOLD) signal evoked by coherent visual motion using functional magnetic resonance imaging (fMRI).

Methods: The subjects underwent 10 min of cathodal and sham tDCS, applied over the right MT+. Following stimulation, random dot kinomatograms (RDK) with different percentages (10%, 30%, 50%) of coherently moving dots were presented.

Results: All motion stimuli activated MT+ in both stimulation conditions. However, cathodal stimulation led to an increase in fMRI signal in MT+ when compared to sham stimulation. This effect did not depend on the coherence level of the visual stimulus.

Conclusions: Here, we show for the first time, that cathodal tDCS stimulation leads to elevated fMRI signal in the human visual cortex.

Citing Articles

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Effects of Transcranial Direct Current Stimulation on Baseline and Slope of Prefrontal Cortex Hemodynamics During a Spatial Working Memory Task.

McKendrick R, Falcone B, Scheldrup M, Ayaz H Front Hum Neurosci. 2020; 14:64.

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Task load modulates tDCS effects on brain network for phonological processing.

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Transcranial Direct Current Stimulation Applied to the Dorsolateral and Ventromedial Prefrontal Cortices in Smokers Modifies Cognitive Circuits Implicated in the Nicotine Withdrawal Syndrome.

Aronson Fischell S, Ross T, Deng Z, Salmeron B, Stein E Biol Psychiatry Cogn Neurosci Neuroimaging. 2020; 5(4):448-460.

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Ota K, Shinya M, Kudo K Front Hum Neurosci. 2019; 13:297.

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