Cytoskeleton As an Emerging Target of Anthrax Toxins

Overview

Journal Toxins (Basel)

Publisher MDPI

Specialty Toxicology

Date 2012 Apr 5

PMID 22474568

Citations 8

Authors

Yannick Trescos

Jean-Nicolas Tournier

Affiliations

Soon will be listed here.

Abstract

Bacillus anthracis, the agent of anthrax, has gained virulence through its exotoxins produced by vegetative bacilli and is composed of three components forming lethal toxin (LT) and edema toxin (ET). So far, little is known about the effects of these toxins on the eukaryotic cytoskeleton. Here, we provide an overview on the general effects of toxin upon the cytoskeleton architecture. Thus, we shall discuss how anthrax toxins interact with their receptors and may disrupt the interface between extracellular matrix and the cytoskeleton. We then analyze what toxin molecular effects on cytoskeleton have been described, before discussing how the cytoskeleton may help the pathogen to corrupt general cell processes such as phagocytosis or vascular integrity.

Citing Articles

The role of anthrax toxin protein receptor 1 as a new mechanosensor molecule and its mechanotransduction in BMSCs under hydrostatic pressure.

Cheng B, Liu Y, Zhao Y, Li Q, Liu Y, Wang J Sci Rep. 2019; 9(1):12642.

PMID: 31477767 PMC: 6718418. DOI: 10.1038/s41598-019-49100-5.

lethal toxin, but not edema toxin, increases pulmonary artery pressure and permeability in isolated perfused rat lungs.

Cui X, Xu W, Neupane P, Weiser-Schlesinger A, Weng R, Pockros B Am J Physiol Heart Circ Physiol. 2019; 316(5):H1076-H1090.

PMID: 30767685 PMC: 6580392. DOI: 10.1152/ajpheart.00685.2018.

The Saccharomyces boulardii CNCM I-745 strain shows protective effects against the B. anthracis LT toxin.

Pontier-Bres R, Rampal P, Peyron J, Munro P, Lemichez E, Czerucka D Toxins (Basel). 2015; 7(11):4455-67.

PMID: 26529015 PMC: 4663514. DOI: 10.3390/toxins7114455.

Micropatterned macrophage analysis reveals global cytoskeleton constraints induced by Bacillus anthracis edema toxin.

Trescos Y, Tessier E, Rougeaux C, Goossens P, Tournier J Infect Immun. 2015; 83(8):3114-25.

PMID: 26015478 PMC: 4496603. DOI: 10.1128/IAI.00479-15.

Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis.

Besschetnova T, Ichimura T, Katebi N, St Croix B, Bonventre J, Olsen B Matrix Biol. 2015; 42:56-73.

PMID: 25572963 PMC: 4409530. DOI: 10.1016/j.matbio.2014.12.002.

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