Transforming Growth Factor-β and Smooth Muscle Differentiation

Overview

Journal World J Biol Chem

Publisher Baishideng Publishing Group

Specialty Biochemistry

Date 2012 Mar 28

PMID 22451850

Citations 55

Authors

Xia Guo

Shi-You Chen

Affiliations

Soon will be listed here.

Abstract

Transforming growth factor (TGF)-β family members are multifunctional cytokines regulating diverse cellular functions such as growth, adhesion, migration, apoptosis, and differentiation. TGF-βs elicit their effects via specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors. Knockout mouse models for the different components of the TGF-β signaling pathway have revealed their critical roles in smooth muscle cell (SMC) differentiation. Genetic studies in humans have linked mutations in these signaling components to specific cardiovascular disorders such as aorta aneurysm and congenital heart diseases due to SMC defects. In this review, the current understanding of TGF-β function in SMC differentiation is highlighted, and the role of TGF-β signaling in SMC-related diseases is discussed.

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