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Epithelial and Mesenchymal Fate Decisions in Wolffian Duct Development

Overview
Specialty Endocrinology
Date 2023 Jun 17
PMID 37330364
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Abstract

Wolffian ducts (WDs) are the paired embryonic structures that give rise to internal male reproductive tract organs. WDs are initially formed in both sexes but have sex-specific fates during sexual differentiation. Understanding WD differentiation requires insights into the process of fate decisions of epithelial and mesenchymal cells, which are tightly coordinated by endocrine, paracrine, and autocrine signals. In this review, we discuss current advances in understanding the fate-decision process of WD epithelial and mesenchymal lineages from their initial formation at the embryonic stage to postnatal differentiation. Finally, we discuss aberrant cell differentiation in WD abnormalities and pathologies and identify opportunities for future investigations.

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References
1.
Kumar M, Syed S, Taketo M, Tanwar P . Epithelial Wnt/βcatenin signalling is essential for epididymal coiling. Dev Biol. 2016; 412(2):234-49. DOI: 10.1016/j.ydbio.2016.02.025. View

2.
Brophy P, Rasmussen M, Parida M, Bonde G, Darbro B, Hong X . A Gene Implicated in Activation of Retinoic Acid Receptor Targets Is a Novel Renal Agenesis Gene in Humans. Genetics. 2017; 207(1):215-228. PMC: 5586373. DOI: 10.1534/genetics.117.1125. View

3.
Murashima A, Miyagawa S, Ogino Y, Nishida-Fukuda H, Araki K, Matsumoto T . Essential roles of androgen signaling in Wolffian duct stabilization and epididymal cell differentiation. Endocrinology. 2011; 152(4):1640-51. PMC: 3060634. DOI: 10.1210/en.2010-1121. View

4.
Sanchez-Ferras O, Pacis A, Sotiropoulou M, Zhang Y, Wang Y, Bourgey M . A coordinated progression of progenitor cell states initiates urinary tract development. Nat Commun. 2021; 12(1):2627. PMC: 8113267. DOI: 10.1038/s41467-021-22931-5. View

5.
Kiyozumi D, Noda T, Yamaguchi R, Tobita T, Matsumura T, Shimada K . NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility. Science. 2020; 368(6495):1132-1135. PMC: 7396227. DOI: 10.1126/science.aay5134. View