Evidence for ACE2-utilizing Coronaviruses (CoVs) Related to Severe Acute Respiratory Syndrome CoV in Bats

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2012 Mar 23

PMID 22438550

Citations 68

Authors

Ann Demogines

Michael Farzan

Sara L Sawyer

Affiliations

Soon will be listed here.

Abstract

In 2002, severe acute respiratory syndrome (SARS)-coronavirus (CoV) appeared as a novel human virus with high similarity to bat coronaviruses. However, while SARS-CoV uses the human angiotensin-converting enzyme 2 (ACE2) receptor for cellular entry, no coronavirus isolated from bats appears to use ACE2. Here we show that signatures of recurrent positive selection in the bat ACE2 gene map almost perfectly to known SARS-CoV interaction surfaces. Our data indicate that ACE2 utilization preceded the emergence of SARS-CoV-like viruses from bats.

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References

Sheahan T, Rockx B, Donaldson E, Corti D, Baric R . Pathways of cross-species transmission of synthetically reconstructed zoonotic severe acute respiratory syndrome coronavirus. J Virol. 2008; 82(17):8721-32. PMC: 2519660. DOI: 10.1128/JVI.00818-08. View

Li F . Structural analysis of major species barriers between humans and palm civets for severe acute respiratory syndrome coronavirus infections. J Virol. 2008; 82(14):6984-91. PMC: 2446986. DOI: 10.1128/JVI.00442-08. View

Wu K, Chen L, Peng G, Zhou W, Pennell C, Mansky L . A virus-binding hot spot on human angiotensin-converting enzyme 2 is critical for binding of two different coronaviruses. J Virol. 2011; 85(11):5331-7. PMC: 3094985. DOI: 10.1128/JVI.02274-10. View

Rest J, Mindell D . SARS associated coronavirus has a recombinant polymerase and coronaviruses have a history of host-shifting. Infect Genet Evol. 2003; 3(3):219-25. PMC: 7129878. DOI: 10.1016/j.meegid.2003.08.001. View

Li W, Zhang C, Sui J, Kuhn J, Moore M, Luo S . Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2. EMBO J. 2005; 24(8):1634-43. PMC: 1142572. DOI: 10.1038/sj.emboj.7600640. View

Becker M, Graham R, Donaldson E, Rockx B, Sims A, Sheahan T . Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice. Proc Natl Acad Sci U S A. 2008; 105(50):19944-9. PMC: 2588415. DOI: 10.1073/pnas.0808116105. View

Holmes E, Rambaut A . Viral evolution and the emergence of SARS coronavirus. Philos Trans R Soc Lond B Biol Sci. 2004; 359(1447):1059-65. PMC: 1693395. DOI: 10.1098/rstb.2004.1478. View

Baranowski E, Domingo E . Evolution of cell recognition by viruses. Science. 2001; 292(5519):1102-5. DOI: 10.1126/science.1058613. View

Yang Z . PAML: a program package for phylogenetic analysis by maximum likelihood. Comput Appl Biosci. 1997; 13(5):555-6. DOI: 10.1093/bioinformatics/13.5.555. View

10.

Kan B, Wang M, Jing H, Xu H, Jiang X, Yan M . Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms. J Virol. 2005; 79(18):11892-900. PMC: 1212604. DOI: 10.1128/JVI.79.18.11892-11900.2005. View

11.

Towler P, Staker B, Prasad S, Menon S, Tang J, Parsons T . ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis. J Biol Chem. 2004; 279(17):17996-8007. PMC: 7980034. DOI: 10.1074/jbc.M311191200. View

12.

Ren W, Qu X, Li W, Han Z, Yu M, Zhou P . Difference in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS-like coronavirus of bat origin. J Virol. 2007; 82(4):1899-907. PMC: 2258702. DOI: 10.1128/JVI.01085-07. View

13.

Lim E, Fregoso O, McCoy C, Matsen F, Malik H, Emerman M . The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx. Cell Host Microbe. 2012; 11(2):194-204. PMC: 3288607. DOI: 10.1016/j.chom.2012.01.004. View

14.

Li W, Shi Z, Yu M, Ren W, Smith C, Epstein J . Bats are natural reservoirs of SARS-like coronaviruses. Science. 2005; 310(5748):676-9. DOI: 10.1126/science.1118391. View

15.

Sheahan T, Rockx B, Donaldson E, Sims A, Pickles R, Corti D . Mechanisms of zoonotic severe acute respiratory syndrome coronavirus host range expansion in human airway epithelium. J Virol. 2007; 82(5):2274-85. PMC: 2258931. DOI: 10.1128/JVI.02041-07. View

16.

Parrish C, Holmes E, Morens D, Park E, Burke D, Calisher C . Cross-species virus transmission and the emergence of new epidemic diseases. Microbiol Mol Biol Rev. 2008; 72(3):457-70. PMC: 2546865. DOI: 10.1128/MMBR.00004-08. View

17.

Graham R, Baric R . Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission. J Virol. 2009; 84(7):3134-46. PMC: 2838128. DOI: 10.1128/JVI.01394-09. View

18.

Wu K, Li W, Peng G, Li F . Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor. Proc Natl Acad Sci U S A. 2009; 106(47):19970-4. PMC: 2785276. DOI: 10.1073/pnas.0908837106. View

19.

Hou Y, Peng C, Yu M, Li Y, Han Z, Li F . Angiotensin-converting enzyme 2 (ACE2) proteins of different bat species confer variable susceptibility to SARS-CoV entry. Arch Virol. 2010; 155(10):1563-9. PMC: 7086629. DOI: 10.1007/s00705-010-0729-6. View

20.

Stavrinides J, Guttman D . Mosaic evolution of the severe acute respiratory syndrome coronavirus. J Virol. 2003; 78(1):76-82. PMC: 303383. DOI: 10.1128/jvi.78.1.76-82.2004. View