Comparison of the Effects of Cholecalciferol and Calcitriol on Calcium Metabolism and Bone Turnover in Chinese Postmenopausal Women with Vitamin D Insufficiency

Overview

Journal Acta Pharmacol Sin

Specialty Pharmacology

Date 2012 Mar 13

PMID 22407227

Citations 6

Authors

Hao Zhang

Qi-Ren Huang

Jie-Mei Gu

Wei-Wei Hu

Yu-Juan Liu

Yun-Qiu Hu

Zhen-Lin Zhang

Affiliations

Soon will be listed here.

Abstract

Aim: To compare the effects of cholecalciferol (800 IU/d) and calcitriol (0.25 μg/d) on calcium metabolism and bone turnover in Chinese postmenopausal women with vitamin D insufficiency.

Methods: One hundred Chinese postmenopausal women aged 63.8±7.0 years and with serum 25-hydroxyvitamin D [25(OH)D] concentration <30 ng/mL were recruited. The subjects were divided into 2 groups based on the age and serum 25(OH)D concentration: 50 subjects (group A) received cholecalciferol (800 IU/d), and 50 subjects (group B) received calcitriol (0.25 μg/d) for 3 months. In addition, all the subjects received Caltrate D (calcium plus 125 IU cholecalciferol) daily in the form of one pill. The markers of calcium metabolism and bone turnover, including the serum levels of calcium, phosphorus, alkaline phosphatase, intact parathyroid hormone, 25(OH)D and β-CrossLaps of type I collagen containing cross-linked C-telopeptide (β-CTX), were measured before and after the intervention.

Results: After the 3-month intervention, the serum 25(OH)D concentration in group A was significantly increased from 16.01 ± 5.0 to 20.02 ± 4.5 ng/mL, while that in group B had no significant change. The serum calcium levels in both the groups were significantly increased (group A: from 2.36 ± 0.1 to 2.45 ± 0.1 mmol/L; group B: from 2.36 ± 0.1 to 2.44 ± 0.1 mmol/L). The levels of serum intact parathyroid hormone in both the groups were significantly decreased (group A: from 48.56 ± 12.8 to 39.59 ± 12.6 pg/mL; group B: from 53.67 ± 20.0 to 40.32 ± 15.4 pg/mL). The serum levels of β-CTX in both the groups were also significantly decreased (group A: from 373.93 ± 135.3 to 325.04 ± 149.0 ng/L; group B: from 431.00 ± 137.1 to 371.74 ± 185.0 ng/L).

Conclusion: We concluded that both cholecalciferol (800 IU/d) and calcitriol (0.25 μg/d) plus Caltrate D modifies the serum calcium and bone turnover markers in Chinese postmenopausal women with vitamin D insufficiency. In addition, cholecalciferol (800 IU/d) significantly increased the serum 25(OH)D concentration.

Citing Articles

Genetic Polymorphisms of Nuclear Factor-κB Family Affect the Bone Mineral Density Response to Zoledronic Acid Therapy in Postmenopausal Chinese Women.

Wang W, He J, Fu W, Wang C, Zhang Z Genes (Basel). 2022; 13(8).

PMID: 36011257 PMC: 9407517. DOI: 10.3390/genes13081343.

Vitamin D Metabolite Profile in Cholecalciferol- or Calcitriol-Supplemented Healthy and Mammary Gland Tumor-Bearing Mice.

Anisiewicz A, Kowalski K, Banach J, Labedz N, Stachowicz-Suhs M, Piotrowska A Nutrients. 2020; 12(11).

PMID: 33172201 PMC: 7695033. DOI: 10.3390/nu12113416.

The Emerging Role of Nutritional Vitamin D in Secondary Hyperparathyroidism in CKD.

Lu C, Yeih D, Hou Y, Jow G, Li Z, Liu W Nutrients. 2018; 10(12).

PMID: 30513912 PMC: 6316278. DOI: 10.3390/nu10121890.

The effects of high-dose calcitriol and individualized exercise on bone metabolism in breast cancer survivors on hormonal therapy: a phase II feasibility trial.

Peppone L, Ling M, Huston A, Reid M, Janelsins M, Puzas J Support Care Cancer. 2018; 26(8):2675-2683.

PMID: 29470705 PMC: 6019129. DOI: 10.1007/s00520-018-4094-4.

The efficacy and safety of weekly 35-mg risedronate dosing regimen for Chinese postmenopausal women with osteoporosis or osteopenia: 1-year data.

Gu J, Wang L, Lin H, Chen D, Tang H, Jin X Acta Pharmacol Sin. 2015; 36(7):841-6.

PMID: 26051110 PMC: 4648111. DOI: 10.1038/aps.2015.30.

References

Vieth R . Why the optimal requirement for Vitamin D3 is probably much higher than what is officially recommended for adults. J Steroid Biochem Mol Biol. 2004; 89-90(1-5):575-9. DOI: 10.1016/j.jsbmb.2004.03.038. View

Seamans K, Hill T, Wallace J, Horigan G, Lucey A, Barnes M . Cholecalciferol supplementation throughout winter does not affect markers of bone turnover in healthy young and elderly adults. J Nutr. 2010; 140(3):454-60. DOI: 10.3945/jn.109.113480. View

von Hurst P, Stonehouse W, Kruger M, Coad J . Vitamin D supplementation suppresses age-induced bone turnover in older women who are vitamin D deficient. J Steroid Biochem Mol Biol. 2010; 121(1-2):293-6. DOI: 10.1016/j.jsbmb.2010.03.054. View

Lau K, Baylink D . Vitamin D therapy of osteoporosis: plain vitamin D therapy versus active vitamin D analog (D-hormone) therapy. Calcif Tissue Int. 1999; 65(4):295-306. DOI: 10.1007/s002239900702. View

Clements M, Davies M, Hayes M, Hickey C, LUMB G, Mawer E . The role of 1,25-dihydroxyvitamin D in the mechanism of acquired vitamin D deficiency. Clin Endocrinol (Oxf). 1992; 37(1):17-27. DOI: 10.1111/j.1365-2265.1992.tb02278.x. View

Heaney R, Davies K, Chen T, Holick M, Barger-Lux M . Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr. 2002; 77(1):204-10. DOI: 10.1093/ajcn/77.1.204. View

Weaver C, Fleet J . Vitamin D requirements: current and future. Am J Clin Nutr. 2004; 80(6 Suppl):1735S-9S. DOI: 10.1093/ajcn/80.6.1735S. View

Eastell R, Hannon R . Biomarkers of bone health and osteoporosis risk. Proc Nutr Soc. 2008; 67(2):157-62. DOI: 10.1017/S002966510800699X. View

Koutkia P, Chen T, Holick M . Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med. 2001; 345(1):66-7. DOI: 10.1056/NEJM200107053450115. View

10.

Morales O, Samuelsson M, Lindgren U, Haldosen L . Effects of 1alpha,25-dihydroxyvitamin D3 and growth hormone on apoptosis and proliferation in UMR 106 osteoblast-like cells. Endocrinology. 2003; 145(1):87-94. DOI: 10.1210/en.2003-0718. View

11.

Seeman E, Delmas P . Bone quality--the material and structural basis of bone strength and fragility. N Engl J Med. 2006; 354(21):2250-61. DOI: 10.1056/NEJMra053077. View

12.

Richy F, Dukas L, Schacht E . Differential effects of D-hormone analogs and native vitamin D on the risk of falls: a comparative meta-analysis. Calcif Tissue Int. 2008; 82(2):102-7. DOI: 10.1007/s00223-008-9102-0. View

13.

Bischoff-Ferrari H, Willett W, Wong J, Giovannucci E, Dietrich T, Dawson-Hughes B . Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA. 2005; 293(18):2257-64. DOI: 10.1001/jama.293.18.2257. View

14.

Halloran B, Bikle D, Levens M, Castro M, Globus R, Holton E . Chronic 1,25-dihydroxyvitamin D3 administration in the rat reduces the serum concentration of 25-hydroxyvitamin D by increasing metabolic clearance rate. J Clin Invest. 1986; 78(3):622-8. PMC: 423635. DOI: 10.1172/JCI112619. View

15.

Holick M, Matsuoka L, Wortsman J . Age, vitamin D, and solar ultraviolet. Lancet. 1989; 2(8671):1104-5. DOI: 10.1016/s0140-6736(89)91124-0. View

16.

Deluca H . Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004; 80(6 Suppl):1689S-96S. DOI: 10.1093/ajcn/80.6.1689S. View

17.

Kuwabara A, Tsugawa N, Tanaka K, Fujii M, Kawai N, Mukae S . Improvement of vitamin D status in Japanese institutionalized elderly by supplementation with 800 IU of vitamin D(3). J Nutr Sci Vitaminol (Tokyo). 2010; 55(6):453-8. DOI: 10.3177/jnsv.55.453. View

18.

CHAPUY M, Pamphile R, Paris E, Kempf C, Schlichting M, Arnaud S . Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study. Osteoporos Int. 2002; 13(3):257-64. DOI: 10.1007/s001980200023. View

19.

Tsukamoto Y, Watanabe T, Nakagami T, Morishita K . Effect of treatment with oral calcitriol on calcium metabolism and fasting serum 25(OH)- or 1,25(OH)2-vitamin D level in Japanese postmenopausal women. Endocr J. 2004; 50(6):681-7. DOI: 10.1507/endocrj.50.681. View

20.

Roux C, Bischoff-Ferrari H, Papapoulos S, de Papp A, West J, Bouillon R . New insights into the role of vitamin D and calcium in osteoporosis management: an expert roundtable discussion. Curr Med Res Opin. 2008; 24(5):1363-70. DOI: 10.1185/030079908x301857. View