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Modulation of Leptin Resistance by Protein Tyrosine Phosphatases

Overview
Journal Cell Metab
Publisher Cell Press
Date 2012 Mar 13
PMID 22405067
Citations 36
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Abstract

Leptin plays a central role in weight control by suppressing food intake and increasing energy expenditure. The concept of leptin resistance emerged to explain the seemingly paradoxical elevated leptin levels in obesity. Recent discoveries reveal that protein tyrosine phosphatases are key players in leptin resistance by globally suppressing leptin signaling.

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