Copper-catalyzed Coupling of 1,1-dibromo-1-alkenes with Phenols: a General, Modular, and Efficient Synthesis of Ynol Ethers, Bromo Enol Ethers, and Ketene Acetals

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2012 Mar 9

PMID 22397691

Citations 3

Authors

Kevin Jouvin

Alexandre Bayle

Frederic Legrand

Gwilherm Evano

Affiliations

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Abstract

An efficient and general copper-catalyzed method is reported for the synthesis of phenol-derived 1-bromoenol ethers, ynol ethers, and ketene acetals by chemodivergent copper-catalyzed cross-coupling between readily available 1,1-dibromo-1-alkenes and phenols.

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