Autoimmune Heart Disease: Role of Sex Hormones and Autoantibodies in Disease Pathogenesis

Overview

Journal Expert Rev Clin Immunol

Specialty Allergy & Immunology

Date 2012 Mar 7

PMID 22390491

Citations 41

Authors

DeLisa Fairweather

Michelle A Petri

Michael J Coronado

Leslie T Cooper

Affiliations

Soon will be listed here.

Abstract

Cardiovascular disease (CVD) and autoimmune diseases (ADs) are the first and third highest causes of death in the USA, respectively. Men have an increased incidence of the majority of CVDs, including atherosclerosis, myocarditis, dilated cardiomyopathy and heart failure. By contrast, nearly 80% of all ADs occur in women. However, in one category of ADs, rheumatic diseases, CVD is the main cause of death. Factors that link rheumatic ADs to CVD are inflammation and the presence of autoantibodies. In this review we will examine recent findings regarding sex differences in the immunopathogenesis of CVD and ADs, explore possible reasons for the increased occurrence of CVD within rheumatic ADs and discuss whether autoantibodies, including rheumatoid factor, could be involved in disease pathogenesis.

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References

Kindermann I, Kindermann M, Kandolf R, Klingel K, Bultmann B, Muller T . Predictors of outcome in patients with suspected myocarditis. Circulation. 2008; 118(6):639-48. DOI: 10.1161/CIRCULATIONAHA.108.769489. View

McCombe P, Greer J, Mackay I . Sexual dimorphism in autoimmune disease. Curr Mol Med. 2009; 9(9):1058-79. DOI: 10.2174/156652409789839116. View

Ronnblom L, Alm G, Eloranta M . Type I interferon and lupus. Curr Opin Rheumatol. 2009; 21(5):471-7. DOI: 10.1097/BOR.0b013e32832e089e. View

Regitz-Zagrosek V, Oertelt-Prigione S, Seeland U, Hetzer R . Sex and gender differences in myocardial hypertrophy and heart failure. Circ J. 2010; 74(7):1265-73. DOI: 10.1253/circj.cj-10-0196. View

Ellis N, Kurahara D, Vohra H, Mascaro-Blanco A, Erdem G, Adderson E . Priming the immune system for heart disease: a perspective on group A streptococci. J Infect Dis. 2010; 202(7):1059-67. DOI: 10.1086/656214. View

Teuscher C, Noubade R, Spach K, McElvany B, Bunn J, Fillmore P . Evidence that the Y chromosome influences autoimmune disease in male and female mice. Proc Natl Acad Sci U S A. 2006; 103(21):8024-9. PMC: 1472423. DOI: 10.1073/pnas.0600536103. View

Newkirk M . Rheumatoid factors: host resistance or autoimmunity?. Clin Immunol. 2002; 104(1):1-13. DOI: 10.1006/clim.2002.5210. View

Kung M, Stork S, Angermann C . [Cardiovascular comorbidity in rheumatic disease. Does sex play a role?]. Herz. 2005; 30(6):512-21. DOI: 10.1007/s00059-005-2717-2. View

Laczik R, Szodoray P, Veres K, Szomjak E, Csipo I, Sipka Jr S . Assessment of IgG antibodies to oxidized LDL in patients with acute coronary syndrome. Lupus. 2011; 20(7):730-5. DOI: 10.1177/0961203311398884. View

10.

Deshpande R, Khalili H, Pergolizzi R, Michael S, Chang M . Estradiol down-regulates LPS-induced cytokine production and NFkB activation in murine macrophages. Am J Reprod Immunol. 1997; 38(1):46-54. DOI: 10.1111/j.1600-0897.1997.tb00275.x. View

11.

Huber S . γδ T lymphocytes kill T regulatory cells through CD1d. Immunology. 2010; 131(2):202-9. PMC: 2967266. DOI: 10.1111/j.1365-2567.2010.03292.x. View

12.

Evans M, Eckert A, Lai K, Adelman S, Harnish D . Reciprocal antagonism between estrogen receptor and NF-kappaB activity in vivo. Circ Res. 2001; 89(9):823-30. DOI: 10.1161/hh2101.098543. View

13.

Nguyen C, Berezne A, Baubet T, Mestre-Stanislas C, Rannou F, Papelard A . Association of gender with clinical expression, quality of life, disability, and depression and anxiety in patients with systemic sclerosis. PLoS One. 2011; 6(3):e17551. PMC: 3052319. DOI: 10.1371/journal.pone.0017551. View

14.

Innala L, Moller B, Ljung L, Magnusson S, Smedby T, Sodergren A . Cardiovascular events in early RA are a result of inflammatory burden and traditional risk factors: a five year prospective study. Arthritis Res Ther. 2011; 13(4):R131. PMC: 3239373. DOI: 10.1186/ar3442. View

15.

Limas C, Goldenberg I, Limas C . Autoantibodies against beta-adrenoceptors in human idiopathic dilated cardiomyopathy. Circ Res. 1989; 64(1):97-103. DOI: 10.1161/01.res.64.1.97. View

16.

Satoh M, Nakamura M, Akatsu T, Iwasaka J, Shimoda Y, Segawa I . Expression of Toll-like receptor 4 is associated with enteroviral replication in human myocarditis. Clin Sci (Lond). 2003; 104(6):577-84. DOI: 10.1042/CS20020263. View

17.

Symmons D, Gabriel S . Epidemiology of CVD in rheumatic disease, with a focus on RA and SLE. Nat Rev Rheumatol. 2011; 7(7):399-408. DOI: 10.1038/nrrheum.2011.75. View

18.

Huber S, Job L, Woodruff J . Sex-related differences in the pattern of coxsackievirus B-3-induced immune spleen cell cytotoxicity against virus-infected myofibers. Infect Immun. 1981; 32(1):68-73. PMC: 350588. DOI: 10.1128/iai.32.1.68-73.1981. View

19.

Sakao S, Tanabe N, Tatsumi K . The estrogen paradox in pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2010; 299(4):L435-8. DOI: 10.1152/ajplung.00057.2010. View

20.

McNamara D, Starling R, Cooper L, Boehmer J, Mather P, Janosko K . Clinical and demographic predictors of outcomes in recent onset dilated cardiomyopathy: results of the IMAC (Intervention in Myocarditis and Acute Cardiomyopathy)-2 study. J Am Coll Cardiol. 2011; 58(11):1112-8. PMC: 6467576. DOI: 10.1016/j.jacc.2011.05.033. View