Delineating an Epigenetic Continuum in Head and Neck Cancer

Overview

Journal Cancer Lett

Specialty Oncology

Date 2012 Mar 6

PMID 22388100

Citations 19

Authors

Maria J Worsham

Josena K Stephen

Kang Mei Chen

Shaleta Havard

Veena Shah

Glendon Gardner

Vanessa G Schweitzer

Affiliations

Soon will be listed here.

Abstract

A tissue field of somatic genetic alterations precedes the histopathological phenotypic changes of carcinoma. Genomic changes could be of potential use in the diagnosis and prognosis of pre-invasive squamous head and neck carcinoma (HNSCC) lesions and as markers for cancer risk assessment. Studies of sequential molecular alterations and genetic progression of pre-invasive HNSCC have not been clearly defined. Studies have shown recurring alterations at chromosome 9p21 (location of the CDKN2A) and TP53 mutations in the early stages of HNSCC. However, gene silencing via hypermethylation is still a relatively new idea in the development of HNSCC and little is known about the contribution of epigenetics to the development of neoplasia, its transformation, progression, and recurrence in HNSCC. This review examines the role of promoter hypermethylation of tumor suppressor genes in the progression continuum from benign papillomas to malignancy in HNSCC.

Citing Articles

Tian X, Shi C, Liu S, Zhao C, Wang X, Cao Y J Dent Sci. 2023; 18(1):57-64.

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High eukaryotic initiation factor 5A2 expression predicts poor prognosis and may participate in the SNHG16/miR-10b-5p/EIF5A2 regulatory axis in head and neck squamous cell carcinoma.

Ye S, Wang D, Jin M, Du J, Chen X, Zhang H J Clin Lab Anal. 2022; 37(1):e24820.

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Epithelial-to-Mesenchymal Transition-Derived Heterogeneity in Head and Neck Squamous Cell Carcinomas.

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