Default Mode Network Abnormalities in Idiopathic Generalized Epilepsy

Overview

Journal Epilepsy Behav

Specialties Neurology
Psychology
Social Sciences

Date 2012 Mar 3

PMID 22381387

Citations 51

Authors

Megan L McGill

Orrin Devinsky

Clare Kelly

Michael Milham

F Xavier Castellanos

Brian T Quinn

Jonathan Dubois

Jonathan R Young

Chad Carlson

Jacqueline French

Ruben Kuzniecky

Eric Halgren

Thomas Thesen

Affiliations

Soon will be listed here.

Abstract

Idiopathic generalized epilepsy (IGE) is associated with widespread cortical network abnormalities on electroencephalography. Resting state functional connectivity (RSFC), based on fMRI, can assess the brain's global functional organization and its disruption in clinical conditions. We compared RSFC associated with the 'default mode network' (DMN) between people with IGE and healthy controls. Strength of functional connectivity within the DMN associated with seeds in the posterior cingulate cortex (PCC) and medial prefrontal cortices (MPFC) was compared between people with IGE and healthy controls and was correlated with seizure duration, age of seizure onset and age at scan. Those with IGE showed markedly reduced functional network connectivity between anterior and posterior cortical seed regions. Seizure duration positively correlates with RSFC between parahippocampal gyri and the PCC but negatively correlates with connectivity between the PCC and frontal lobe. The observed pattern of disruption provides evidence for integration- and segregation-type network abnormalities and supports aberrant network organization among people with IGE.

Citing Articles

Power Spectral Density and Default Mode Network Connectivity in Generalized Epilepsy Syndromes: What to Expect from Drug-Resistant Patients.

Bistriceanu C, Vulpoi G, Ciubotaru A, Stoleriu I, Cuciureanu D Biomedicines. 2025; 12(12.

PMID: 39767663 PMC: 11673858. DOI: 10.3390/biomedicines12122756.

Advances in the fMRI analysis of the default mode network: a review.

Sanz-Morales E, Melero H Brain Struct Funct. 2024; 230(1):22.

PMID: 39738718 DOI: 10.1007/s00429-024-02888-z.

Altered effective connectivity of the default mode network in juvenile myoclonic epilepsy.

Ke M, Wang F, Liu G Cogn Neurodyn. 2024; 18(4):1549-1561.

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Magnetic resonance imaging in canine idiopathic epilepsy: a mini-review.

Foss K, Billhymer A Front Vet Sci. 2024; 11:1427403.

PMID: 39021411 PMC: 11251927. DOI: 10.3389/fvets.2024.1427403.

Alterations in spatiotemporal characteristics of dynamic networks in juvenile myoclonic epilepsy.

Ke M, Luo X, Guo Y, Zhang J, Ren X, Liu G Neurol Sci. 2024; 45(10):4983-4996.

PMID: 38704479 DOI: 10.1007/s10072-024-07506-8.

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