Altered Functional Connectivity in Default Mode Network in Absence Epilepsy: a Resting-state FMRI Study

Overview

Journal Hum Brain Mapp

Publisher Wiley

Specialty Neurology

Date 2011 Feb 15

PMID 21319269

Citations 126

Authors

Cheng Luo

Qifu Li

Yongxiu Lai

Yang Xia

Yun Qin

Wei Liao

Shasha Li

Dong Zhou

Dezhong Yao

Qiyong Gong

Affiliations

Soon will be listed here.

Abstract

Dysfunctional default mode network (DMN) has been observed in various mental disorders, including epilepsy (see review Broyd et al. [2009]: Neurosci Biobehav Rev 33:279–296). Because interictal epileptic discharges may affect DMN, resting-state fMRI was used in this study to determine DMN functional connectivity in 14 healthy controls and 12 absence epilepsy patients. To avoid interictal epileptic discharge effects, testing was performed within interictal durations when there were no interictal epileptic discharges. Cross-correlation functional connectivity analysis with seed at posterior cingulate cortex, as well as region-wise calculation in DMN, revealed decreased integration within DMN in the absence epilepsy patients. Region-wise functional connectivity among the frontal, parietal, and temporal lobe was significantly decreased in the patient group. Moreover, functional connectivity between the frontal and parietal lobe revealed a significant negative correlation with epilepsy duration. These findings indicated DMN abnormalities in patients with absence epilepsy, even during resting interictal durations without interictal epileptic discharges. Abnormal functional connectivity in absence epilepsy may reflect abnormal anatomo-functional architectural integration in DMN, as a result of cognitive mental impairment and unconsciousness during absence seizure.

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