Estradiol Increases Hematopoietic Stem and Progenitor Cells Independent of Its Actions on Bone

Overview

Journal Haematologica

Specialty Hematology

Date 2012 Feb 29

PMID 22371175

Citations 17

Authors

Anett Illing

Peng Liu

Susanne Ostermay

Arndt Schilling

Gerald de Haan

Andree Krust

Michael Amling

Pierre Chambon

Thorsten Schinke

Jan P Tuckermann

Affiliations

Soon will be listed here.

Abstract

Hematopoietic stem and progenitor cells reside in vascular and endosteal niches in the bone marrow. Factors affecting bone remodeling were reported to influence numbers and mobilization of hematopoietic stem cells. We therefore analyzed the effects of estradiol acting anabolic on bone integrity. Here we observe that estradiol increases progenitor cell numbers in the vascular but not in the endosteal compartment independent of its estrogen receptor α-dependent anabolic bone effects. Hematopoietic progenitors capable of reconstituting lethally irradiated mice are increased by enhanced cell cycle entry, leading to a diminished long-term reconstitution potential after serial transplantation. We demonstrate that estradiol action on stromal cells potently favors hematopoietic progenitor/stem cell frequency accompanied by enhanced expression of cell adhesion molecules. Finally, estradiol treatment enhances retention of hematopoietic stem cells in the vascular niche of the bone marrow. We describe for the first time the mechanism of estrogen action on hematopoietic stem and progenitor cells.

Citing Articles

Influence of donor-recipient sex on engraftment of normal and leukemia stem cells in xenotransplantation.

Mian S, Ariza-McNaughton L, Anjos-Afonso F, Guring R, Jackson S, Kizilors A Hemasphere. 2024; 8(5):e80.

PMID: 38774656 PMC: 11107397. DOI: 10.1002/hem3.80.

Sexual dimorphism in aging hematopoiesis: an earlier decline of hematopoietic stem and progenitor cells in male than female mice.

So E, Jeong E, Wu K, Dubielecka P, Reginato A, Quesenberry P Aging (Albany NY). 2020; 12(24):25939-25955.

PMID: 33378745 PMC: 7803521. DOI: 10.18632/aging.202167.

Advances in preclinical hematopoietic stem cell models and possible implications for improving therapeutic transplantation.

Fraint E, Ulloa B, Norberto M, Potts K, Bowman T Stem Cells Transl Med. 2020; 10(3):337-345.

PMID: 33058566 PMC: 7900582. DOI: 10.1002/sctm.20-0294.

Natural estrogens enhance the engraftment of human hematopoietic stem and progenitor cells in immunodeficient mice.

Fananas-Baquero S, Orman I, Becerra Aparicio F, Bermudez de Miguel S, Garcia Merino J, Yanez R Haematologica. 2020; 106(6):1659-1670.

PMID: 32354868 PMC: 8168497. DOI: 10.3324/haematol.2019.233924.

Estrogen Receptors Alpha and Beta in Acute Myeloid Leukemia.

Roma A, Spagnuolo P Cancers (Basel). 2020; 12(4).

PMID: 32276421 PMC: 7226505. DOI: 10.3390/cancers12040907.

References

Szilvassy S, Nicolini F, Eaves C, Miller C . Quantitation of murine and human hematopoietic stem cells by limiting-dilution analysis in competitively repopulated hosts. Methods Mol Med. 2011; 63:167-87. DOI: 10.1385/1-59259-140-X:167. View

Muller-Sieburg C, Sieburg H . Stem cell aging: survival of the laziest?. Cell Cycle. 2008; 7(24):3798-804. PMC: 2746656. DOI: 10.4161/cc.7.24.7214. View

Tuckermann J, Kleiman A, Moriggl R, Spanbroek R, Neumann A, Illing A . Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy. J Clin Invest. 2007; 117(5):1381-90. PMC: 1849982. DOI: 10.1172/JCI28034. View

Vidal O, Lindberg M, Savendahl L, Lubahn D, Ritzen E, Gustafsson J . Disproportional body growth in female estrogen receptor-alpha-inactivated mice. Biochem Biophys Res Commun. 1999; 265(2):569-71. DOI: 10.1006/bbrc.1999.1711. View

Samuels A, Perry M, Tobias J . High-dose estrogen induces de novo medullary bone formation in female mice. J Bone Miner Res. 1999; 14(2):178-86. DOI: 10.1359/jbmr.1999.14.2.178. View

Sims N, Dupont S, Krust A, Clement-Lacroix P, Minet D, Resche-Rigon M . Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males. Bone. 2002; 30(1):18-25. DOI: 10.1016/s8756-3282(01)00643-3. View

Trumpp A, Refaeli Y, Oskarsson T, Gasser S, Murphy M, Martin G . c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature. 2001; 414(6865):768-73. DOI: 10.1038/414768a. View

Nilsson S, Johnston H, Coverdale J . Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell niches. Blood. 2001; 97(8):2293-9. DOI: 10.1182/blood.v97.8.2293. View

Lindberg M, Weihua Z, Andersson N, Moverare S, Gao H, Vidal O . Estrogen receptor specificity for the effects of estrogen in ovariectomized mice. J Endocrinol. 2002; 174(2):167-78. DOI: 10.1677/joe.0.1740167. View

10.

Arai F, Hirao A, Ohmura M, Sato H, Matsuoka S, Takubo K . Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell. 2004; 118(2):149-61. DOI: 10.1016/j.cell.2004.07.004. View

11.

Windahl S, Norgard M, Kuiper G, Gustafsson J, Andersson G . Cellular distribution of estrogen receptor beta in neonatal rat bone. Bone. 2000; 26(2):117-21. DOI: 10.1016/s8756-3282(99)00248-3. View

12.

Sugiyama T, Kohara H, Noda M, Nagasawa T . Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity. 2006; 25(6):977-88. DOI: 10.1016/j.immuni.2006.10.016. View

13.

Kamminga L, van Os R, Ausema A, Noach E, Weersing E, Dontje B . Impaired hematopoietic stem cell functioning after serial transplantation and during normal aging. Stem Cells. 2004; 23(1):82-92. DOI: 10.1634/stemcells.2004-0066. View

14.

Calvi L, Adams G, Weibrecht K, Weber J, Olson D, Knight M . Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003; 425(6960):841-6. DOI: 10.1038/nature02040. View

15.

Nilsson S, Makela S, Treuter E, Tujague M, Thomsen J, Andersson G . Mechanisms of estrogen action. Physiol Rev. 2001; 81(4):1535-65. DOI: 10.1152/physrev.2001.81.4.1535. View

16.

van Os R, Dethmers-Ausema B, de Haan G . In vitro assays for cobblestone area-forming cells, LTC-IC, and CFU-C. Methods Mol Biol. 2008; 430:143-57. DOI: 10.1007/978-1-59745-182-6_10. View

17.

Fuchs E, Tumbar T, Guasch G . Socializing with the neighbors: stem cells and their niche. Cell. 2004; 116(6):769-78. DOI: 10.1016/s0092-8674(04)00255-7. View

18.

Manolagas S . From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev. 2010; 31(3):266-300. PMC: 3365845. DOI: 10.1210/er.2009-0024. View

19.

Rauch A, Seitz S, Baschant U, Schilling A, Illing A, Stride B . Glucocorticoids suppress bone formation by attenuating osteoblast differentiation via the monomeric glucocorticoid receptor. Cell Metab. 2010; 11(6):517-31. DOI: 10.1016/j.cmet.2010.05.005. View

20.

Zhang J, Niu C, Ye L, Huang H, He X, Tong W . Identification of the haematopoietic stem cell niche and control of the niche size. Nature. 2003; 425(6960):836-41. DOI: 10.1038/nature02041. View