Chronic Kidney Disease Associated with Perinatal HIV Infection in Children and Adolescents

Overview

Journal Pediatr Nephrol

Specialties Nephrology
Pediatrics

Date 2012 Feb 28

PMID 22366874

Citations 11

Authors

Murli U Purswani

Miriam C Chernoff

Charles D Mitchell

George R Seage 3rd

Gaston Zilleruelo

Carolyn Abitbol

Warren A Andiman

Kathleen A Kaiser

Hans Spiegel

James M Oleske

Affiliations

Soon will be listed here.

Abstract

Background: This study describes the incidence, clinical and demographic characteristics, and spectrum of chronic kidney disease (CKD) in youths with perinatal HIV-1 infection.

Methods: Retrospective analysis between May 1993 and December 2006 of subjects with renal disease followed in the Pediatric AIDS Clinical Trials Group 219/219C multicenter study examining the long-term consequences of perinatal HIV infection. Diagnosis confirmation was made utilizing a questionnaire mailed to research sites. Participants with CKD of other etiology than HIV were excluded. Outcome measures were biopsy-diagnosed CKD and, in the absence of biopsy, HIV-associated nephropathy (HIVAN) using established clinical criteria.

Results: Questionnaires on 191 out of 2,102 participants identified 27 cases of CKD: 14 biopsy-diagnosed and 6 clinical cases of HIVAN, and 7 biopsy-diagnosed cases of immune complex-mediated kidney disease (lupus-like nephritis, 3; IgA nephropathy, 2; membranous nephropathy, 2). Incidence rates for CKD associated with HIV in pre-highly active antiretroviral therapy (HAART) (1993-1997) and HAART (1998-2002, 2003-2006) eras were 0.43, 2.84, and 2.79 events per 1,000 person years respectively. In multivariate analysis, black race and viral load ≥100,000 copies/mL (rate ratios 3.28 and 5.05, p ≤ 0.02) were associated with CKD.

Conclusions: A variety of immune complex-mediated glomerulonephritides and HIVAN occurs in this population. Black race and uncontrolled viral replication are risk factors for CKD associated with HIV.

Citing Articles

Comparison of the prevalence and associated factors of chronic kidney disease diagnosed by serum creatinine or cystatin C among young people living with HIV in Uganda.

Nasuuna E, Tomlinson L, Kalyesubula R, Dziva Chikwari C, Castelnuovo B, Manabe Y BMC Nephrol. 2024; 25(1):422.

PMID: 39587464 PMC: 11590532. DOI: 10.1186/s12882-024-03865-8.

Prevalence of chronic kidney disease among young people living with HIV in Sub Saharan Africa: A systematic review and meta-analysis.

Nasuuna E, Nanyeenya N, Kibirige D, Izudi J, Dziva Chikwari C, Kalyesubula R PLoS One. 2024; 19(11):e0301954.

PMID: 39495780 PMC: 11534254. DOI: 10.1371/journal.pone.0301954.

Comparison of the prevalence and associated factors of chronic kidney disease diagnosed by serum creatinine or cystatin C among young people living with HIV in Uganda.

Nasuuna E, Tomlinson L, Kalyesubula R, Dziva Chikwari C, Castelnuovo B, Manabe Y medRxiv. 2024; .

PMID: 39281729 PMC: 11398437. DOI: 10.1101/2024.09.02.24312932.

HIV-Associated CKDs in Children and Adolescents.

Beng H, Rakhmanina N, Moudgil A, Tuchman S, Ahn S, Griffith C Kidney Int Rep. 2020; 5(12):2292-2300.

PMID: 33305123 PMC: 7710839. DOI: 10.1016/j.ekir.2020.09.001.

Blood-borne viral infections in pediatric hemodialysis.

Menon S, Munshi R Pediatr Nephrol. 2018; 34(6):1019-1031.

PMID: 30032326 DOI: 10.1007/s00467-018-4019-y.

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