Antioxidants of Therapeutic Relevance in COPD from the Neotropical Blueberry Anthopterus Wardii

Overview

Journal Food Chem

Specialties Chemistry
Nutritional Sciences

Date 2012 Feb 25

PMID 22363097

Citations 14

Authors

Gema Flores

Keyvan Dastmalchi

Abdoulaye J Dabo

Kathleen Whalen

Paola Pedraza-Penalosa

Robert F Foronjy

Jeanine M DArmiento

Edward J Kennelly

Affiliations

Soon will be listed here.

Abstract

Four flavone C-glycosides, isoorientin (1), orientin (2), vitexin (3), and isovitexin (4), were isolated from the neotropical blueberry of Anthopterus wardii, a so-called "superfruit", using antioxidant activity-guided fractionation. A dose-response relationship of compounds 1-4 was determined for their anti-inflammatory activity against interleukin-8 (IL-8) and for the inhibition of matrix metalloproteinase-1 (MMP-1) expression, an inflammatory marker for chronic obstructive pulmonary disease. The four flavone C-glycosides exhibited inhibitory activity against IL-8 production and MMP-1 expression, with compounds 1, 3, and 4 having the most potent inhibitory activities in both assays at 100 μg/ml. The structures of compounds 1-4 were determined by spectroscopic methods. These flavone C-glycosides are reported for the first time in the Anthopterus genus.

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