Heparin-binding Growth Factors and Their Receptors

Overview

Journal Cytotechnology

Specialties Biotechnology
Genetics

Date 2012 Feb 24

PMID 22358874

Citations 2

Authors

B B Olwin

Affiliations

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Abstract

Heparin-binding growth factors modulate diverse biological activities including cellular proliferation, cellular differentiation, morphogenesis, and angiogenesis. Biochemical characterization for two members of the heparin-binding growth factor family, acidic and basic fibroblast growth factors, is extensive, while characterization of the remaining five members is forthcoming. Cell surface receptors have been identified for acidic and basic fibroblast growth factors, but little is known concerning their sites of action in vivo or the mechanisms involved in transducing the energy of growth factor binding to a biological response. An understanding of the biological basis for the diversity of the heparin binding growth factor family and the in vivo actions of these factors will prove a major challenge to future research efforts.

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References

DiSorbo D, Shi E, McKeehan W . Purification form human hepatoma cells of a 130-kDa membrane glycoprotein with properties of the heparin-binding growth factor receptor. Biochem Biophys Res Commun. 1988; 157(3):1007-14. DOI: 10.1016/s0006-291x(88)80974-4. View

Paterno G, Gillespie L, Dixon M, Slack J, Heath J . Mesoderm-inducing properties of INT-2 and kFGF: two oncogene-encoded growth factors related to FGF. Development. 1989; 106(1):79-83. DOI: 10.1242/dev.106.1.79. View

Linkhart T, Clegg C, Hauschika S . Myogenic differentiation in permanent clonal mouse myoblast cell lines: regulation by macromolecular growth factors in the culture medium. Dev Biol. 1981; 86(1):19-30. DOI: 10.1016/0012-1606(81)90311-0. View

Thomas K, Fitzpatrick S . Purification and characterization of acidic fibroblast growth factor from bovine brain. Proc Natl Acad Sci U S A. 1984; 81(2):357-61. PMC: 344675. DOI: 10.1073/pnas.81.2.357. View

Florkiewicz R, Sommer A . Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons. Proc Natl Acad Sci U S A. 1989; 86(11):3978-81. PMC: 287371. DOI: 10.1073/pnas.86.11.3978. View

Klagsbrun M, Smith S, Sullivan R, Shing Y, Davidson S, Smith J . Multiple forms of basic fibroblast growth factor: amino-terminal cleavages by tumor cell- and brain cell-derived acid proteinases. Proc Natl Acad Sci U S A. 1987; 84(7):1839-43. PMC: 304536. DOI: 10.1073/pnas.84.7.1839. View

Navre M, Ringold G . A growth factor-repressible gene associated with protein kinase C-mediated inhibition of adipocyte differentiation. J Cell Biol. 1988; 107(1):279-86. PMC: 2115191. DOI: 10.1083/jcb.107.1.279. View

Burgess W, Maciag T . The heparin-binding (fibroblast) growth factor family of proteins. Annu Rev Biochem. 1989; 58:575-606. DOI: 10.1146/annurev.bi.58.070189.003043. View

Brown K, Blakeley D, Brigstock D . Stimulation of polyphosphoinositide hydrolysis in Swiss 3T3 cells by recombinant fibroblast growth factors. FEBS Lett. 1989; 247(2):227-31. DOI: 10.1016/0014-5793(89)81340-7. View

10.

Braunhut S, Gudas L, Kurokawa T, Sasse J, DAmore P . Expression of fibroblast growth factor by F9 teratocarcinoma cells as a function of differentiation. J Cell Biol. 1989; 108(6):2467-76. PMC: 2115611. DOI: 10.1083/jcb.108.6.2467. View

11.

Tsuda T, Kaibuchi K, Kawahara Y, Fukuzaki H, Takai Y . Induction of protein kinase C activation and Ca2+ mobilization by fibroblast growth factor in Swiss 3T3 cells. FEBS Lett. 1985; 191(2):205-10. DOI: 10.1016/0014-5793(85)80009-0. View

12.

Rubin J, Osada H, Finch P, Taylor W, Rudikoff S, Aaronson S . Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci U S A. 1989; 86(3):802-6. PMC: 286565. DOI: 10.1073/pnas.86.3.802. View

13.

Togari A, Dickens G, Kuzuya H, Guroff G . The effect of fibroblast growth factor on PC12 cells. J Neurosci. 1985; 5(2):307-16. PMC: 6565190. View

14.

Olwin B, Hauschka S . Fibroblast growth factor receptor levels decrease during chick embryogenesis. J Cell Biol. 1990; 110(2):503-9. PMC: 2115997. DOI: 10.1083/jcb.110.2.503. View

15.

Lobb R, Fett J . Purification of two distinct growth factors from bovine neural tissue by heparin affinity chromatography. Biochemistry. 1984; 23(26):6295-9. DOI: 10.1021/bi00321a001. View

16.

Mansson P, Adams P, Kan M, McKeehan W . Heparin-binding growth factor gene expression and receptor characteristics in normal rat prostate and two transplantable rat prostate tumors. Cancer Res. 1989; 49(9):2485-94. View

17.

Pasquale E, Maher P, Singer S . Comparative study of the tyrosine phosphorylation of proteins in Swiss 3T3 fibroblasts stimulated by a variety of mitogenic agents. J Cell Physiol. 1988; 137(1):146-56. DOI: 10.1002/jcp.1041370118. View

18.

Tucker R, Chang D . Effects of platelet-derived growth factor and fibroblast growth factor on free intracellular calcium and mitogenesis. J Cell Biochem. 1989; 39(2):139-51. DOI: 10.1002/jcb.240390206. View

19.

Vigny M, Lavigne M, Fayein N, Jeanny J, Laurent M, Courtois Y . Specific binding of basic fibroblast growth factor to basement membrane-like structures and to purified heparan sulfate proteoglycan of the EHS tumor. J Cell Physiol. 1988; 137(2):321-8. DOI: 10.1002/jcp.1041370216. View

20.

Lobb R, Harper J, Fett J . Purification of heparin-binding growth factors. Anal Biochem. 1986; 154(1):1-14. DOI: 10.1016/0003-2697(86)90487-2. View