Functional Studies of MicroRNAs in Neural Stem Cells: Problems and Perspectives

Overview

Journal Front Neurosci

Date 2012 Feb 21

PMID 22347160

Citations 19

Authors

Malin Akerblom

Rohit Sachdeva

Johan Jakobsson

Affiliations

Soon will be listed here.

Abstract

In adult mammals, neural stem cells (NSCs) are found in two niches of the brain; the subventricular zone by the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. Neurogenesis is a complex process that is tightly controlled on a molecular level. Recently, microRNAs (miRNAs) have been implicated to play a central role in the regulation of NCSs. miRNAs are small, endogenously expressed RNAs that regulate gene expression at the post-transcriptional level. However, functional studies of miRNAs are complicated due to current technical limitations. In this review we describe recent findings about miRNAs in NSCs looking closely at miR-124, miR-9, and let-7. In addition, we highlight technical strategies used to investigate miRNA function, accentuating limitations, and potentials.

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