Manipulations of Cholinesterase Gene Expression Modulate Murine Megakaryocytopoiesis in Vitro

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 1990 Nov 1

PMID 2233731

Citations 7

Authors

D Patinkin

S Seidman

F Eckstein

F Benseler

H Zakut

H Soreq

Affiliations

Soon will be listed here.

Abstract

Megakaryocytopoiesis was selectively inhibited in cultured murine bone marrow cells by a 15-mer oligodeoxynucleotide complementary to the initiator AUG region in butyrylcholinesterase mRNA. Furthermore, conditioned medium from Xenopus oocytes producing recombinant butyrylcholinesterase stimulated megakaryocytopoiesis. These observations implicate butyrylcholinesterase in megakaryocytopoiesis and suggest application of oligodeoxynucleotides for modulating bone marrow development.

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