The Human Gene Encoding Acetylcholinesterase is Located on the Long Arm of Chromosome 7

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 1992 Jul 1

PMID 1609795

Citations 15

Authors

D K Getman

J H Eubanks

S Camp

G A Evans

P Taylor

Affiliations

Soon will be listed here.

Abstract

Acetylcholinesterase (AChE) is a secreted enzyme essential for regulating cholinergic neurotransmission at neuronal and neuromuscular synapses. In view of the altered expression of AChE in some central neurological and neuromuscular disorders with a probable genetic basis, we have identified the chromosomal location of the gene encoding AChE. Chromosomal in situ suppression hybridization analysis revealed a single gene to be at 7q22, a result which was confirmed by PCR analysis of genomic DNA from a human/hamster somatic cell hybrid containing a single human chromosome 7. The AChE gene thus maps to the same region in which frequent nonrandom chromosome 7 deletions occur in leukemias of myeloid cell precursors known to express the enzyme during normal differentiation.

Citing Articles

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Changes in the Acetylcholinesterase Enzymatic Activity in Tumor Development and Progression.

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Characterization of butyrylcholinesterase from porcine milk.

Saxena A, Belinskaya T, Schopfer L, Lockridge O Arch Biochem Biophys. 2018; 652:38-49.

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Role of acetylcholinesterase in lung cancer.

Xi H, Wu R, Liu J, Zhang L, Li Z Thorac Cancer. 2015; 6(4):390-8.

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