Striatal Dopamine in Bulimia Nervosa: a PET Imaging Study

Overview

Journal Int J Eat Disord

Publisher Wiley

Specialty Social Sciences

Date 2012 Feb 15

PMID 22331810

Citations 34

Authors

Allegra Broft

Rebecca Shingleton

Jenna Kaufman

Fei Liu

Dileep Kumar

Mark Slifstein

Anissa Abi-Dargham

Janet Schebendach

Ronald Van Heertum

Evelyn Attia

Diana Martinez

B Timothy Walsh

Affiliations

Soon will be listed here.

Abstract

Objective: Bulimia nervosa (BN) has been characterized as similar to an addiction, though the empirical support for this characterization is limited. This study utilized PET imaging to determine whether abnormalities in brain dopamine (DA) similar to those described in substance use disorders occur in BN.

Method: PET imaging with [(11) C]raclopride, pre/post methylphenidate administration, to assess dopamine type 2 (D(2)) receptor binding (BP(ND)) and striatal DA release (ΔBP(ND)).

Results: There was a trend toward lower D(2) receptor BP(ND) in two striatal subregions in the patient group when compared with the control group. DA release in the putamen in the patient group was significantly reduced and, overall, there was a trend toward a difference in striatal DA release. Striatal DA release was significantly associated with the frequency of binge eating.

Discussion: These data suggest that BN is characterized by abnormalities in brain DA that resemble, in some ways, those described in addictive disorders.

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