» Articles » PMID: 1975644

Molecular Cloning and Characterization of a Novel Dopamine Receptor (D3) As a Target for Neuroleptics

Overview
Journal Nature
Specialty Science
Date 1990 Sep 13
PMID 1975644
Citations 521
Authors
Affiliations
Soon will be listed here.
Abstract

A dopamine receptor has been characterized which differs in its pharmacology and signalling system from the D1 or D2 receptor and represents both an autoreceptor and a postsynaptic receptor. The D3 receptor is localized to limbic areas of the brain, which are associated with cognitive, emotional and endocrine functions. It seems to mediate some of the effects of antipsychotic drugs and drugs used against Parkinson's disease, that were previously thought to interact only with D2 receptors.

Citing Articles

Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors.

Enriquez-Traba J, Arenivar M, Yarur-Castillo H, Noh C, Flores R, Weil T Nat Neurosci. 2024; 28(1):105-121.

PMID: 39653808 DOI: 10.1038/s41593-024-01819-9.


Dopaminergic Epistases in Schizophrenia.

Bosun A, Albu-Kalinovic R, Neda-Stepan O, Bosun I, Farcas S, Enatescu V Brain Sci. 2024; 14(11).

PMID: 39595853 PMC: 11592377. DOI: 10.3390/brainsci14111089.


Linkers in Bitopic Agonists Shape Bias Profile among Transducers for the Dopamine D2 and D3 Receptors.

Semeano A, Garland R, Bonifazi A, Lee K, Famiglietti J, Zhang W ACS Pharmacol Transl Sci. 2024; 7(8):2333-2349.

PMID: 39144557 PMC: 11320723. DOI: 10.1021/acsptsci.4c00119.


Genetic polymorphisms and their association with neurobiological and psychological factors in anorexia nervosa: a systematic review.

Almaghrbi H, Bawadi H Front Psychol. 2024; 15:1386233.

PMID: 38979077 PMC: 11229080. DOI: 10.3389/fpsyg.2024.1386233.


Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction.

Tizabi Y, Getachew B, Hauser S, Tsytsarev V, Manhaes A, da Silva V Brain Sci. 2024; 14(6).

PMID: 38928557 PMC: 11201416. DOI: 10.3390/brainsci14060558.