MicroRNAs and Ovarian Function

Overview

Journal J Ovarian Res

Publisher Biomed Central

Specialties Gynecology & Obstetrics
Reproductive Medicine

Date 2012 Feb 11

PMID 22321819

Citations 35

Authors

Jason Baley

Julang Li

Affiliations

Soon will be listed here.

Abstract

MicroRNAs (miRNAs) are a class of small non-coding RNAs which function in gene regulation with an important role in cell proliferation, maturation, and activity. The regulatory role of these small RNA molecules has recently begun to be explored in ovarian cells, uncovering their influence on gonadal development, steroidogenesis, apoptosis, ovulation, and corpus luteum development. This emerging area of research has extended and reshaped our understanding on how ovarian function is regulated. Here, we review the current understanding of miRNA biogenesis, the role and mechanism that miRNAs play in post-transcriptional gene expression regulation, and specifically the current evidence of miRNA involvement in ovarian development and function. Future comprehensive understanding of the role of miRNAs in the ovary in both physiological and pathological conditions may offer new treatment strategies for infertility and other ovarian disorders.

Citing Articles

A glance into the roles of microRNAs (exosomal and non-exosomal) in polycystic ovary syndrome.

Masoudi Chelegahi A, Ebrahimi S, Reiisi S, Nezamnia M Obstet Gynecol Sci. 2023; 67(1):30-48.

PMID: 38050353 PMC: 10792310. DOI: 10.5468/ogs.23193.

Role of miRNAs interference on ovarian functions and premature ovarian failure.

Nouri N, Shareghi-Oskoue O, Aghebati-Maleki L, Danaii S, Heris J, Soltani-Zangbar M Cell Commun Signal. 2022; 20(1):198.

PMID: 36564840 PMC: 9783981. DOI: 10.1186/s12964-022-00992-3.

MicroRNA 195-5p Targets Promoter Region to Regulate Its Expression in Granulosa Cells.

Bai Y, Pan B, Zhan X, Silver H, Li J Int J Mol Sci. 2021; 22(13).

PMID: 34201585 PMC: 8267755. DOI: 10.3390/ijms22136721.

High Expression of miR-204 in Chicken Atrophic Ovaries Promotes Granulosa Cell Apoptosis and Inhibits Autophagy.

Cui Z, Liu L, Amevor F, Zhu Q, Wang Y, Li D Front Cell Dev Biol. 2020; 8:580072.

PMID: 33251211 PMC: 7676916. DOI: 10.3389/fcell.2020.580072.

miR-458b-5p regulates ovarian granulosa cells proliferation through Wnt/β-catenin signaling pathway by targeting catenin beta-1.

Wang W, Teng J, Han X, Zhang S, Zhang Q, Tang H Anim Biosci. 2020; 34(6):957-966.

PMID: 33152225 PMC: 8100484. DOI: 10.5713/ajas.20.0392.

References

Torley K, Silveira J, Smith P, Anthony R, Veeramachaneni D, Winger Q . Expression of miRNAs in ovine fetal gonads: potential role in gonadal differentiation. Reprod Biol Endocrinol. 2011; 9:2. PMC: 3027096. DOI: 10.1186/1477-7827-9-2. View

Sirotkin A, Ovcharenko D, Grossmann R, Laukova M, Mlyncek M . Identification of microRNAs controlling human ovarian cell steroidogenesis via a genome-scale screen. J Cell Physiol. 2009; 219(2):415-20. DOI: 10.1002/jcp.21689. View

Doench J, Petersen C, Sharp P . siRNAs can function as miRNAs. Genes Dev. 2003; 17(4):438-42. PMC: 195999. DOI: 10.1101/gad.1064703. View

Xu S, Linher-Melville K, Yang B, Wu D, Li J . Micro-RNA378 (miR-378) regulates ovarian estradiol production by targeting aromatase. Endocrinology. 2011; 152(10):3941-51. PMC: 3176644. DOI: 10.1210/en.2011-1147. View

Nelson L, Bulun S . Estrogen production and action. J Am Acad Dermatol. 2001; 45(3 Suppl):S116-24. DOI: 10.1067/mjd.2001.117432. View

Kiriakidou M, Tan G, Lamprinaki S, de Planell-Saguer M, Nelson P, Mourelatos Z . An mRNA m7G cap binding-like motif within human Ago2 represses translation. Cell. 2007; 129(6):1141-51. DOI: 10.1016/j.cell.2007.05.016. View

Carletti M, Fiedler S, Christenson L . MicroRNA 21 blocks apoptosis in mouse periovulatory granulosa cells. Biol Reprod. 2010; 83(2):286-95. PMC: 2907287. DOI: 10.1095/biolreprod.109.081448. View

Otsuka M, Zheng M, Hayashi M, Lee J, Yoshino O, Lin S . Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice. J Clin Invest. 2008; 118(5):1944-54. PMC: 2289794. DOI: 10.1172/JCI33680. View

Shimasaki S, Zachow R, Li D, Kim H, Iemura S, Ueno N . A functional bone morphogenetic protein system in the ovary. Proc Natl Acad Sci U S A. 1999; 96(13):7282-7. PMC: 22077. DOI: 10.1073/pnas.96.13.7282. View

10.

Zeng Y, Cullen B . Sequence requirements for micro RNA processing and function in human cells. RNA. 2003; 9(1):112-23. PMC: 1370375. DOI: 10.1261/rna.2780503. View

11.

Nissan T, Parker R . Computational analysis of miRNA-mediated repression of translation: implications for models of translation initiation inhibition. RNA. 2008; 14(8):1480-91. PMC: 2491470. DOI: 10.1261/rna.1072808. View

12.

Carthew R, Sontheimer E . Origins and Mechanisms of miRNAs and siRNAs. Cell. 2009; 136(4):642-55. PMC: 2675692. DOI: 10.1016/j.cell.2009.01.035. View

13.

Wang Y, Medvid R, Melton C, Jaenisch R, Blelloch R . DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet. 2007; 39(3):380-5. PMC: 3008549. DOI: 10.1038/ng1969. View

14.

Sasson R, Dantes A, Tajima K, Amsterdam A . Novel genes modulated by FSH in normal and immortalized FSH-responsive cells: new insights into the mechanism of FSH action. FASEB J. 2003; 17(10):1256-66. DOI: 10.1096/fj.02-0740com. View

15.

Yao G, Yin M, Lian J, Tian H, Liu L, Li X . MicroRNA-224 is involved in transforming growth factor-beta-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4. Mol Endocrinol. 2010; 24(3):540-51. PMC: 5419098. DOI: 10.1210/me.2009-0432. View

16.

Fiedler S, Carletti M, Hong X, Christenson L . Hormonal regulation of MicroRNA expression in periovulatory mouse mural granulosa cells. Biol Reprod. 2008; 79(6):1030-7. PMC: 2780477. DOI: 10.1095/biolreprod.108.069690. View

17.

Murchison E, Stein P, Xuan Z, Pan H, Zhang M, Schultz R . Critical roles for Dicer in the female germline. Genes Dev. 2007; 21(6):682-93. PMC: 1820942. DOI: 10.1101/gad.1521307. View

18.

Ruby J, Jan C, Bartel D . Intronic microRNA precursors that bypass Drosha processing. Nature. 2007; 448(7149):83-6. PMC: 2475599. DOI: 10.1038/nature05983. View

19.

Tripurani S, Lee K, Wee G, Smith G, Yao J . MicroRNA-196a regulates bovine newborn ovary homeobox gene (NOBOX) expression during early embryogenesis. BMC Dev Biol. 2011; 11:25. PMC: 3103443. DOI: 10.1186/1471-213X-11-25. View

20.

Iorio M, Visone R, Di Leva G, Donati V, Petrocca F, Casalini P . MicroRNA signatures in human ovarian cancer. Cancer Res. 2007; 67(18):8699-707. DOI: 10.1158/0008-5472.CAN-07-1936. View