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Independent Vesicle Pools Underlie Different Modes of Release During Neuronal Development

Overview
Journal J Neurosci
Specialty Neurology
Date 2012 Feb 4
PMID 22302825
Citations 38
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Abstract

Mature presynaptic terminals release neurotransmitter both in response to activity and spontaneously. We found that axons of rat hippocampal neurons initially show very high levels of exclusively spontaneous release, which progressively switches over to the mature phenotype during synapse formation. These two modes of vesicle cycling derive from distinct pools throughout development and the initiation of activity-dependent release was independent of postsynaptic contacts, suggesting it is an autonomous presynaptic event.

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