Vesicle Transport Through Interaction with T-SNAREs 1a (Vti1a)'s Roles in Neurons

Overview

Journal Heliyon

Specialty Social Sciences

Date 2020 Aug 11

PMID 32775753

Citations 9

Authors

Bor Luen Tang

Affiliations

Soon will be listed here.

Abstract

The Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family mediates membrane fusion during membrane trafficking and autophagy in all eukaryotic cells, with a number of SNAREs having cell type-specific functions. The endosome--Golgi network (TGN) localized SNARE, Vesicle transport through interaction with t-SNAREs 1A (Vti1a), is unique among SNAREs in that it has numerous neuron-specific functions. These include neurite outgrowth, nervous system development, spontaneous neurotransmission, synaptic vesicle and dense core vesicle secretion, as well as a process of unconventional surface transport of the Kv4 potassium channel. Furthermore, the human gene is known to form fusion products with neighboring genes in cancer tissues, and variants are associated with risk in cancers, including glioma. In this review, I highlight VTI1A's known physio-pathological roles in brain neurons, as well as unanswered questions in these regards.

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