Transmission of Influenza B Viruses in the Guinea Pig

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2012 Feb 4

PMID 22301149

Citations 45

Authors

Natalie Pica

Yi-Ying Chou

Nicole M Bouvier

Peter Palese

Affiliations

Soon will be listed here.

Abstract

Epidemic influenza is typically caused by infection with viruses of the A and B types and can result in substantial morbidity and mortality during a given season. Here we demonstrate that influenza B viruses can replicate in the upper respiratory tract of the guinea pig and that viruses of the two main lineages can be transmitted with 100% efficiency between inoculated and naïve animals in both contact and noncontact models. Our results also indicate that, like in the case for influenza A virus, transmission of influenza B viruses is enhanced at colder temperatures, providing an explanation for the seasonality of influenza epidemics in temperate climates. We therefore present, for the first time, a small animal model with which to study the underlying mechanisms of influenza B virus transmission.

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