Cholinergic Regulation of Airway Inflammation and Remodelling

Overview

Journal J Allergy (Cairo)

Specialty Allergy & Immunology

Date 2012 Feb 1

PMID 22291719

Citations 20

Authors

Saeed Kolahian

Reinoud Gosens

Affiliations

Soon will be listed here.

Abstract

Acetylcholine is the predominant parasympathetic neurotransmitter in the airways that regulates bronchoconstriction and mucus secretion. Recent findings suggest that acetylcholine regulates additional functions in the airways, including inflammation and remodelling during inflammatory airway diseases. Moreover, it has become apparent that acetylcholine is synthesized by nonneuronal cells and tissues, including inflammatory cells and structural cells. In this paper, we will discuss the regulatory role of acetylcholine in inflammation and remodelling in which we will focus on the role of the airway smooth muscle cell as a target cell for acetylcholine that modulates inflammation and remodelling during respiratory diseases such as asthma and COPD.

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