Regular Spiking and Intrinsic Bursting Pyramidal Cells Show Orthogonal Forms of Experience-dependent Plasticity in Layer V of Barrel Cortex

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2012 Jan 31

PMID 22284191

Citations 53

Authors

Vincent Jacob

Leopoldo Petreanu

Nick Wright

Karel Svoboda

Kevin Fox

Affiliations

Soon will be listed here.

Abstract

Most functional plasticity studies in the cortex have focused on layers (L) II/III and IV, whereas relatively little is known of LV. Structural measurements of dendritic spines in vivo suggest some specialization among LV cell subtypes. We therefore studied experience-dependent plasticity in the barrel cortex using intracellular recordings to distinguish regular spiking (RS) and intrinsic bursting (IB) subtypes. Postsynaptic potentials and suprathreshold responses in vivo revealed a remarkable dichotomy in RS and IB cell plasticity; spared whisker potentiation occurred in IB but not RS cells while deprived whisker depression occurred in RS but not IB cells. Similar RS/IB differences were found in the LII/III to V connections in brain slices. Modeling studies showed that subthreshold changes predicted the suprathreshold changes. These studies demonstrate the major functional partition of plasticity within a single cortical layer and reveal the LII/III to LV connection as a major excitatory locus of cortical plasticity.

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