Translational Study of MicroRNAs and Its Application in Kidney Disease and Hypertension Research

Overview

Journal Clin Sci (Lond)

Specialties Biochemistry
General Medicine
Science

Date 2012 Jan 31

PMID 22283365

Citations 11

Authors

Alison J Kriegel

Domagoj Mladinov

Mingyu Liang

Affiliations

Soon will be listed here.

Abstract

MicroRNA research in humans and mammalian model organisms is in a crucial stage of development. Diagnostic and therapeutic values of microRNAs appear promising, but remain to be established. The physiological and pathophysiological significance of microRNAs is generally recognized, but much better understood in some organ systems and disease areas than others. In the present paper, we review several translational studies of microRNAs, including those showing the potential value of therapeutic agents targeting microRNAs and diagnostic or prognostic microRNA markers detectable in body fluids. We discuss the lessons learned and the experience gained from these studies. Several recent studies have begun to explore translational microRNA research in kidney disease and hypertension. Translational research of microRNAs in the kidney faces unique challenges, but provides many opportunities to develop and apply new methods, and to merge complementary basic and clinical approaches.

Citing Articles

Genetic and Epigenetic Mechanisms Regulating Blood Pressure and Kidney Dysfunction.

Pandey K Hypertension. 2024; 81(7):1424-1437.

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Exosomal miRNAs in urine associated with children's cardiorenal parameters: a cross-sectional study.

Levin-Schwartz Y, Curtin P, Flores D, Aushev V, Tamayo-Ortiz M, Svensson K Epigenomics. 2021; 13(7):499-512.

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Endogenous miR-204 Protects the Kidney against Chronic Injury in Hypertension and Diabetes.

Cheng Y, Wang D, Wang F, Liu J, Huang B, Baker M J Am Soc Nephrol. 2020; 31(7):1539-1554.

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miRNA-34a inhibits cell adhesion by targeting CD44 in human renal epithelial cells: implications for renal stone disease.

Wang B, He G, Xu G, Wen J, Yu X Urolithiasis. 2019; 48(2):109-116.

PMID: 31506763 DOI: 10.1007/s00240-019-01155-9.

Animal Models of Hypertension: A Scientific Statement From the American Heart Association.

Lerman L, Kurtz T, Touyz R, Ellison D, Chade A, Crowley S Hypertension. 2019; 73(6):e87-e120.

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