MicroRNAs: Powerful New Regulators of Heart Disease and Provocative Therapeutic Targets

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2007 Sep 6

PMID 17786230

Citations 257

Authors

Eva Van Rooij

Eric N Olson

Affiliations

Soon will be listed here.

Abstract

MicroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Recent studies have revealed key roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart, providing glimpses of undiscovered regulatory mechanisms and potential therapeutic targets for the treatment of heart disease.

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