Clinical Correlates of Periodic Limb Movements in Sleep in Parkinson's Disease

Overview

Journal J Neurol Sci

Publisher Elsevier

Specialty Neurology

Date 2012 Jan 27

PMID 22277375

Citations 19

Authors

Naima Covassin

Ariel B Neikrug

Lianqi Liu

Jody Corey-Bloom

Jose S Loredo

Barton W Palmer

Jeanne Maglione

Sonia Ancoli-Israel

Affiliations

Soon will be listed here.

Abstract

Objective: The aim of the current study was to investigate the frequency of periodic limb movements in sleep (PLMS) in Parkinson's disease (PD) and their impact on nocturnal sleep and daytime functioning.

Methods: Forty-five PD patients (mean age 68.5 ± 8.7 years; 32 males) underwent one night of polysomnography (PSG). Clinical assessment and questionnaires evaluating sleep disturbance and quality of life (QoL) were completed. Patients were divided into two groups based on their PLMS index (PLMSI): PLMSI ≥ 15 (PLMS+) and PLMSI <15 (PLMS-).

Results: There were 26 (57.8%) PD patients in the PLMS+group and 19 (42.2%) patients in the PLMS-group. Subjective assessment revealed an association between PLMS+status and greater PD symptom severity, more subjective sleep disturbance, and decreased QoL. All patients showed poor sleep, and no significant group differences were detected on PSG measures.

Conclusion: We observed that PLMS occurred frequently in PD and increased with more severe PD. Although PLMS did not affect objective sleep, it was associated with increased sleep complaints and reduced QoL. Overall, our findings support the association between PLMS and PD as well as the clinical relevance of sleep disturbances in PD.

Citing Articles

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References

Peto V, Jenkinson C, Fitzpatrick R, Greenhall R . The development and validation of a short measure of functioning and well being for individuals with Parkinson's disease. Qual Life Res. 1995; 4(3):241-8. DOI: 10.1007/BF02260863. View

Askenasy J . Sleep in Parkinson's disease. Acta Neurol Scand. 1993; 87(3):167-70. DOI: 10.1111/j.1600-0404.1993.tb04095.x. View

Scaglione C, Vignatelli L, Plazzi G, Marchese R, Negrotti A, Rizzo G . REM sleep behaviour disorder in Parkinson's disease: a questionnaire-based study. Neurol Sci. 2005; 25(6):316-21. DOI: 10.1007/s10072-004-0364-7. View

Coleman R, Pollak C, Weitzman E . Periodic movements in sleep (nocturnal myoclonus): relation to sleep disorders. Ann Neurol. 1980; 8(4):416-21. DOI: 10.1002/ana.410080413. View

Briellmann R, Mathis J, Bassetti C, Gugger M, Hess C . Patterns of muscle activity in legs in sleep apnea patients before and during nCPAP therapy. Eur Neurol. 1997; 38(2):113-8. DOI: 10.1159/000113173. View

Chaudhuri K, Martinez-Martin P, Schapira A, Stocchi F, Sethi K, Odin P . International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: the NMSQuest study. Mov Disord. 2006; 21(7):916-23. DOI: 10.1002/mds.20844. View

Wetter T, Stiasny K, Winkelmann J, Buhlinger A, Brandenburg U, Penzel T . A randomized controlled study of pergolide in patients with restless legs syndrome. Neurology. 1999; 52(5):944-50. DOI: 10.1212/wnl.52.5.944. View

Voderholzer U, Muller N, Haag C, Riemann D, Straube A . Periodic limb movements during sleep are a frequent finding in patients with Gilles de la Tourette's syndrome. J Neurol. 1997; 244(8):521-6. DOI: 10.1007/s004150050136. View

Happe S, Pirker W, Klosch G, Sauter C, Zeitlhofer J . Periodic leg movements in patients with Parkinson's disease are associated with reduced striatal dopamine transporter binding. J Neurol. 2003; 250(1):83-6. DOI: 10.1007/s00415-003-0957-8. View

10.

Rosenthal L, Roehrs T, Sicklesteel J, Zorick F, Wittig R, Roth T . Periodic movements during sleep, sleep fragmentation, and sleep-wake complaints. Sleep. 1984; 7(4):326-30. DOI: 10.1093/sleep/7.4.326. View

11.

de Mello M, Silva A, Esteves A, Tufik S . Reduction of periodic leg movement in individuals with paraplegia following aerobic physical exercise. Spinal Cord. 2002; 40(12):646-9. DOI: 10.1038/sj.sc.3101381. View

12.

Hornyak M, Trenkwalder C . Restless legs syndrome and periodic limb movement disorder in the elderly. J Psychosom Res. 2004; 56(5):543-8. DOI: 10.1016/S0022-3999(04)00020-0. View

13.

HOEHN M, Yahr M . Parkinsonism: onset, progression and mortality. Neurology. 1967; 17(5):427-42. DOI: 10.1212/wnl.17.5.427. View

14.

Carrier J, Frenette S, Montplaisir J, Paquet J, Drapeau C, Morettini J . Effects of periodic leg movements during sleep in middle-aged subjects without sleep complaints. Mov Disord. 2005; 20(9):1127-32. DOI: 10.1002/mds.20506. View

15.

Claman D, Redline S, Blackwell T, Ancoli-Israel S, Surovec S, Scott N . Prevalence and correlates of periodic limb movements in older women. J Clin Sleep Med. 2007; 2(4):438-45. View

16.

Nicolas A, Lesperance P, Montplaisir J . Is excessive daytime sleepiness with periodic leg movements during sleep a specific diagnostic category?. Eur Neurol. 1998; 40(1):22-6. DOI: 10.1159/000007951. View

17.

Scaravilli T, Gasparoli E, Rinaldi F, Polesello G, Bracco F . Health-related quality of life and sleep disorders in Parkinson's disease. Neurol Sci. 2003; 24(3):209-10. DOI: 10.1007/s10072-003-0134-y. View

18.

Brodeur C, Montplaisir J, Godbout R, MARINIER R . Treatment of restless legs syndrome and periodic movements during sleep with L-dopa: a double-blind, controlled study. Neurology. 1988; 38(12):1845-8. DOI: 10.1212/wnl.38.12.1845. View

19.

Allen R, Picchietti D, Hening W, Trenkwalder C, Walters A, Montplaisi J . Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003; 4(2):101-19. DOI: 10.1016/s1389-9457(03)00010-8. View

20.

Arnulf I, Konofal E, Merino-Andreu M, Houeto J, Mesnage V, Welter M . Parkinson's disease and sleepiness: an integral part of PD. Neurology. 2002; 58(7):1019-24. DOI: 10.1212/wnl.58.7.1019. View