Liver-specific MicroRNA-122: Biogenesis and Function

Overview

Journal RNA Biol

Specialty Molecular Biology

Date 2012 Jan 20

PMID 22258222

Citations 201

Authors

Catherine Jopling

Affiliations

Soon will be listed here.

Abstract

microRNA-122 (miR-122) was one of the first examples of a tissue-specific miRNA. It is highly expressed in liver, where it constitutes 70% of the total miRNA pool. miR-122 expression is specific to the vertebrate lineage, where the sequence of the mature miRNA is completely conserved. miR-122 is a target for extensive study due to its association with cholesterol metabolism and hepatocellular carcinoma, and its important role in promoting hepatitis C virus (HCV) replication. This review will discuss the biogenesis and function of miR-122.

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