A Molecular Mechanism for Modulating Plasma Zn Speciation by Fatty Acids

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2012 Jan 14

PMID 22239162

Citations 23

Authors

Jin Lu

Alan J Stewart

Darrell Sleep

Peter J Sadler

Teresa J T Pinheiro

Claudia A Blindauer

Affiliations

Soon will be listed here.

Abstract

Albumin transports both fatty acids and zinc in plasma. Competitive binding studied by isothermal titration calorimetry revealed that physiologically relevant levels of fatty acids modulate the Zn-binding capacity of albumin, with far-reaching implications for biological zinc speciation. The molecular mechanism for this effect is likely due to a large conformational change elicited by fatty acid binding to a high-affinity interdomain site that disrupts at least one Zn site. Albumin may be a molecular device to "translate" certain aspects of the organismal energy state into global zinc signals.

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